G3BP2 (G3BP stress granule assembly factor 2)

2007-08-01  

Identity

HGNC
G3BP2
LOCATION
4q21.1
LOCUSID
9908
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9908
HGNC: 30291
Ensembl: ENSG00000138757

Variants:

dbSNP: 9908
ClinVar: 9908
TCGA: ENSG00000138757
COSMIC: G3BP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138757ENST00000357854Q9UN86
ENSG00000138757ENST00000357854A0A024RDB2
ENSG00000138757ENST00000359707Q9UN86
ENSG00000138757ENST00000359707A0A024RDE5
ENSG00000138757ENST00000395719Q9UN86
ENSG00000138757ENST00000395719A0A024RDE5
ENSG00000138757ENST00000499709D6R9X5
ENSG00000138757ENST00000503660D6RB17
ENSG00000138757ENST00000507252D6RBR0
ENSG00000138757ENST00000507745D6RAC7
ENSG00000138757ENST00000508510D6R9A4
ENSG00000138757ENST00000509100D6RGJ4
ENSG00000138757ENST00000509561D6RBM9
ENSG00000138757ENST00000510902H0YAE3
ENSG00000138757ENST00000511146D6RBW8
ENSG00000138757ENST00000511868D6REX8
ENSG00000138757ENST00000515457D6RE13

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386409832024Exosomal miRNA-92a derived from cancer-associated fibroblasts promote invasion and metastasis in breast cancer by regulating G3BP2.1
386409832024Exosomal miRNA-92a derived from cancer-associated fibroblasts promote invasion and metastasis in breast cancer by regulating G3BP2.1
368789032023USP7- and PRMT5-dependent G3BP2 stabilization drives de novo lipogenesis and tumorigenesis of HNSC.6
374610192023Chemotherapy-induced exosomal circBACH1 promotes breast cancer resistance and stemness via miR-217/G3BP2 signaling pathway.5
368789032023USP7- and PRMT5-dependent G3BP2 stabilization drives de novo lipogenesis and tumorigenesis of HNSC.6
374610192023Chemotherapy-induced exosomal circBACH1 promotes breast cancer resistance and stemness via miR-217/G3BP2 signaling pathway.5
357613862022EBF1-mediated up-regulation of lncRNA FGD5-AS1 facilitates osteosarcoma progression by regulating miR-124-3p/G3BP2 axis as a ceRNA.5
357613862022EBF1-mediated up-regulation of lncRNA FGD5-AS1 facilitates osteosarcoma progression by regulating miR-124-3p/G3BP2 axis as a ceRNA.5
334764862021BAALC-AS1/G3BP2/c-Myc feedback loop promotes cell proliferation in esophageal squamous cell carcinoma.11
334976112021G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling.45
345170252021Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagation.10
345214232021MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer.23
334764862021BAALC-AS1/G3BP2/c-Myc feedback loop promotes cell proliferation in esophageal squamous cell carcinoma.11
334976112021G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling.45
345170252021Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagation.10

Citation

Dessen P

G3BP2 (G3BP stress granule assembly factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-08-01

Online version: http://atlasgeneticsoncology.org/gene/47700/g3bp2-(g3bp-stress-granule-assembly-factor-2)