NTN4 (netrin 4)

2007-08-01  

Identity

HGNC
NTN4
LOCATION
12q22
LOCUSID
59277
ALIAS
PRO3091
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 59277
MIM: 610401
HGNC: 13658
Ensembl: ENSG00000074527

Variants:

dbSNP: 59277
ClinVar: 59277
TCGA: ENSG00000074527
COSMIC: NTN4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000074527ENST00000343702Q9HB63
ENSG00000074527ENST00000344911Q9HB63
ENSG00000074527ENST00000538383Q9HB63
ENSG00000074527ENST00000547980F8W0I7
ENSG00000074527ENST00000553059Q9HB63

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Extracellular matrix organizationREACTOMER-HSA-1474244
Non-integrin membrane-ECM interactionsREACTOMER-HSA-3000171
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
363505382023Netrin-4: Focus on Its Role in Axon Guidance, Tissue Stability, Angiogenesis and Tumors.3
378006322023RNA‑binding protein quaking 5 inhibits the progression of non‑small cell lung cancer by upregulating netrin‑4 expression.0
381568652023Hepatic Expression of NTN4 and Its Receptors in Patients with Hepatocellular Carcinoma.0
363505382023Netrin-4: Focus on Its Role in Axon Guidance, Tissue Stability, Angiogenesis and Tumors.3
378006322023RNA‑binding protein quaking 5 inhibits the progression of non‑small cell lung cancer by upregulating netrin‑4 expression.0
381568652023Hepatic Expression of NTN4 and Its Receptors in Patients with Hepatocellular Carcinoma.0
352326662022The Interaction of NTN4 and miR-17-92 Polymorphisms on Breast Cancer Susceptibility in a Chinese Population.1
357328552022NTN4 as a prognostic marker and a hallmark for immune infiltration in breast cancer.5
352326662022The Interaction of NTN4 and miR-17-92 Polymorphisms on Breast Cancer Susceptibility in a Chinese Population.1
357328552022NTN4 as a prognostic marker and a hallmark for immune infiltration in breast cancer.5
336363962021Netrin-4 expression by human endothelial cells inhibits endothelial inflammation and senescence.7
339230952021Anti-Inflammatory Role of Netrin-4 in Diabetic Retinopathy.3
336363962021Netrin-4 expression by human endothelial cells inhibits endothelial inflammation and senescence.7
339230952021Anti-Inflammatory Role of Netrin-4 in Diabetic Retinopathy.3
314945792020Enrichment of damaging missense variants in genes related with axonal guidance signalling in sporadic Meniere's disease.9

Citation

Dessen P

NTN4 (netrin 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-08-01

Online version: http://atlasgeneticsoncology.org/gene/47709/ntn4-(netrin-4)