CARS (cysteinyj-tRNA synthetase)
2003-08-01 Jean-Loup Huret , Sylvie Senon AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Identity
HGNC
LOCATION
11p15.4
LOCUSID
ALIAS
CARS,CYSRS,MCDDBH,MDBH,MGC:11246
FUSION GENES
DNA/RNA
Description
The gene spans 57 kb; 22 exons; 2,5 kb cDNA
Transcription
alternate splicing
Proteins
Description
748 amino acids, 85 kDa. Forms homodimers
Localisation
cytoplasmic
Implicated in
Entity name
Inflammatory myofibroblastic tumors with a complex t(2;11)(p23;p15)
Disease
rare soft tissue tumour found in children and young adults
Prognosis
good prognosis
Hybrid gene
5 CARS - 3 ALK
Fusion protein
N-term CARS (606 amino acids) fused to the usual 562 C-term amino acids of ALK
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 12112524 | 2002 | Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor. | Cools J et al |
Citation
Jean-Loup Huret ; Sylvie Senon
CARS (cysteinyj-tRNA synthetase)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/484/cars-(cysteinyj-trna-synthetase)
