ABI2 (abl interactor 2)

2003-02-01  

Identity

HGNC
LOCATION
2q33.2
LOCUSID
ALIAS
ABI-2,ABI2B,AIP-1,AIP1,AblBP3,SSH3BP2,argBP1,argBPIA,argBPIB
FUSION GENES

Other Information

Locus ID:

NCBI: 10152
MIM: 606442
HGNC: 24011
Ensembl: ENSG00000138443

Variants:

dbSNP: 10152
ClinVar: 10152
TCGA: ENSG00000138443
COSMIC: ABI2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138443ENST00000261016B7Z836
ENSG00000138443ENST00000261017Q9NYB9
ENSG00000138443ENST00000261018F8WAL6
ENSG00000138443ENST00000295851F8WAL6
ENSG00000138443ENST00000413635F8WAU3
ENSG00000138443ENST00000416001F8WBL5
ENSG00000138443ENST00000417864E7EP65
ENSG00000138443ENST00000422511E7EW77
ENSG00000138443ENST00000424558A0A0C4DG21
ENSG00000138443ENST00000425253F8WCD7
ENSG00000138443ENST00000430418E9PEZ7
ENSG00000138443ENST00000431886F8WEB9
ENSG00000138443ENST00000441061F8WAQ3
ENSG00000138443ENST00000444584E7EUA1
ENSG00000138443ENST00000447762F8WAZ8
ENSG00000138443ENST00000451591H7C3Q7
ENSG00000138443ENST00000454023H0Y6B5

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Regulation of actin cytoskeletonKEGGhsa04810
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate WASPs and WAVEsREACTOMER-HSA-5663213

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
370428422023PIM1 phosphorylates ABI2 to enhance actin dynamics and promote tumor invasion.3
370428422023PIM1 phosphorylates ABI2 to enhance actin dynamics and promote tumor invasion.3
324966562020Association of Abl interactor 2, ABI2, with platelet/lymphocyte ratio in patients with renal cell carcinoma: A pilot study.2
324966562020Association of Abl interactor 2, ABI2, with platelet/lymphocyte ratio in patients with renal cell carcinoma: A pilot study.2
279323142017TIS21(/BTG2) inhibits doxorubicin-induced stress fiber-vimentin networks via Nox4-ROS-ABI2-DRF-linked signal cascade.2
279323142017TIS21(/BTG2) inhibits doxorubicin-induced stress fiber-vimentin networks via Nox4-ROS-ABI2-DRF-linked signal cascade.2
223048322012Abl-interactor 2 (ABI2): a novel MLL translocation partner in acute myeloid leukemia.4
223048322012Abl-interactor 2 (ABI2): a novel MLL translocation partner in acute myeloid leukemia.4
191582782009Regulation of cell-cell adhesion by Abi/Diaphanous complexes.63
191582782009Regulation of cell-cell adhesion by Abi/Diaphanous complexes.63
186326092008Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2.59
186326092008Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2.59
173896882007Bcr-Abl induces abnormal cytoskeleton remodeling, beta1 integrin clustering and increased cell adhesion to fibronectin through the Abl interactor 1 pathway.26
173896882007Bcr-Abl induces abnormal cytoskeleton remodeling, beta1 integrin clustering and increased cell adhesion to fibronectin through the Abl interactor 1 pathway.26
164889062006The expression of Abl interactor 2 in leiomyoma and myometrium and regulation by GnRH analogue and transforming growth factor-beta.1

Citation

Dessen P

ABI2 (abl interactor 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/494/abi2-(abl-interactor-2)