USP28 (ubiquitin specific peptidase 28)

2007-09-01  

Identity

HGNC
LOCATION
11q23.2
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 57646
MIM: 610748
HGNC: 12625
Ensembl: ENSG00000048028

Variants:

dbSNP: 57646
ClinVar: 57646
TCGA: ENSG00000048028
COSMIC: USP28

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000048028ENST00000003302Q96RU2
ENSG00000048028ENST00000535607H0YFA0
ENSG00000048028ENST00000537490H0YH19
ENSG00000048028ENST00000537642H0YFX3
ENSG00000048028ENST00000537706Q96RU2
ENSG00000048028ENST00000538224H0YFT9
ENSG00000048028ENST00000538475H0YG96
ENSG00000048028ENST00000540438F5GZ74
ENSG00000048028ENST00000540925F5H2G4
ENSG00000048028ENST00000544750F5H6Q3
ENSG00000048028ENST00000544967G3V1N5
ENSG00000048028ENST00000545540B4E3L3
ENSG00000048028ENST00000545608H0YFD7

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382279442024The dimeric deubiquitinase USP28 integrates 53BP1 and MYC functions to limit DNA damage.0
384982222024USP28 promotes tumorigenesis and cisplatin resistance by deubiquitinating MAST1 protein in cancer cells.0
385472922024Control of cell proliferation by memories of mitosis.2
382279442024The dimeric deubiquitinase USP28 integrates 53BP1 and MYC functions to limit DNA damage.0
384982222024USP28 promotes tumorigenesis and cisplatin resistance by deubiquitinating MAST1 protein in cancer cells.0
385472922024Control of cell proliferation by memories of mitosis.2
364426242023Inhibition of deubiquitinase USP28 attenuates cyst growth in autosomal dominant polycystic kidney disease.0
372303882023The deubiquitinase USP28 maintains the expression of the transcription factor MYCN and is essential in neuroblastoma cells.0
374504152023Comprehensive prognostic and immunological analysis of Ubiquitin Specific Peptidase 28 in pan-cancers and identification of its role in hepatocellular carcinoma cell lines.0
364426242023Inhibition of deubiquitinase USP28 attenuates cyst growth in autosomal dominant polycystic kidney disease.0
372303882023The deubiquitinase USP28 maintains the expression of the transcription factor MYCN and is essential in neuroblastoma cells.0
374504152023Comprehensive prognostic and immunological analysis of Ubiquitin Specific Peptidase 28 in pan-cancers and identification of its role in hepatocellular carcinoma cell lines.0
348228422022The deubiquitinase USP28 stabilizes the expression of RecQ family helicases and maintains the viability of triple negative breast cancer cells.7
349626182022Loss of USP28 and SPINT2 expression promotes cancer cell survival after whole genome doubling.8
353646272022USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K.3

Citation

Dessen P

USP28 (ubiquitin specific peptidase 28)

Atlas Genet Cytogenet Oncol Haematol. 2007-09-01

Online version: http://atlasgeneticsoncology.org/gene/49733