CCL17 (C-C motif chemokine ligand 17)

2007-09-01 Affiliation

Identity

HGNC

CCL17

LOCATION

16q21

LOCUSID

6361

ALIAS

A-152E5.3,ABCD-2,SCYA17,TARC

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6361
MIM: 601520
HGNC: 10615
Ensembl: ENSG00000102970

Variants:

dbSNP: 6361
ClinVar: 6361
TCGA: ENSG00000102970
COSMIC: CCL17

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000102970	ENST00000219244	Q92583
ENSG00000102970	ENST00000616880	Q92583

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Chemokine signaling pathway	KEGG	ko04062
Chemokine signaling pathway	KEGG	hsa04062
IL-17 signaling pathway	KEGG	ko04657
IL-17 signaling pathway	KEGG	hsa04657

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15944327	2005	Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity.	231
12949249	2003	Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.	154
18224687	2008	CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3+ regulatory T cells in gastric cancer.	104
17703412	2007	Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.	100
16859899	2006	Thymus and activation regulated chemokine (TARC)/CCL17 and skin diseases.	46
14747532	2004	Selective induction of Th2-attracting chemokines CCL17 and CCL22 in human B cells by latent membrane protein 1 of Epstein-Barr virus.	45
22981793	2012	Phenotypic characterization of lung macrophages in asthmatic patients: overexpression of CCL17.	44
15113590	2004	Both Th2 and Th1 chemokines (TARC/CCL17, MDC/CCL22, and Mig/CXCL9) are elevated in sera from patients with atopic dermatitis.	39
27525438	2016	Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation.	36
14734737	2004	E-selectin, thymus- and activation-regulated chemokine/CCL17, and intercellular adhesion molecule-1 are constitutively coexpressed in dermal microvessels: a foundation for a cutaneous immunosurveillance system.	34

Citation

Dessen P

CCL17 (C-C motif chemokine ligand 17)

Atlas Genet Cytogenet Oncol Haematol. 2007-09-01

Online version: http://atlasgeneticsoncology.org/gene/49742/ccl17-(c-c-motif-chemokine-ligand-17)