SRCIN1 (SRC kinase signaling inhibitor 1)

2007-09-01 Affiliation

Identity

HGNC

SRCIN1

LOCATION

17q12

LOCUSID

80725

ALIAS

P140,SNIP

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 80725
MIM: 610786
HGNC: 29506
Ensembl: ENSG00000277363

Variants:

dbSNP: 80725
ClinVar: 80725
TCGA: ENSG00000277363
COSMIC: SRCIN1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000277363	ENST00000612431	A0A087WU33
ENSG00000277363	ENST00000613927	A0A087WTE6
ENSG00000277363	ENST00000617146	Q9C0H9
ENSG00000277363	ENST00000621492	A0A087X165
ENSG00000277363	ENST00000622190	A0A087WVV7
ENSG00000277363	ENST00000622519	A0A590UJ70

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37169737	2023	p140Cap inhibits β-Catenin in the breast cancer stem cell compartment instructing a protective anti-tumor immune response.	3
37169737	2023	p140Cap inhibits β-Catenin in the breast cancer stem cell compartment instructing a protective anti-tumor immune response.	3
33079227	2021	The p140Cap adaptor protein as a molecular hub to block cancer aggressiveness.	4
33079227	2021	The p140Cap adaptor protein as a molecular hub to block cancer aggressiveness.	4
31285546	2020	The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma.	11
32323798	2020	lncRNA TPTEP1 competitively sponges miR‑328‑5p to inhibit the proliferation of non‑small cell lung cancer cells.	16
32924985	2020	FOXD3-AS1 suppresses the progression of non-small cell lung cancer by regulating miR-150/SRCIN1axis.	8
32964035	2020	SRCIN1 Regulated by circCCDC66/miR-211 Is Upregulated and Promotes Cell Proliferation in Non-Small-Cell Lung Cancer.	8
31285546	2020	The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma.	11
32323798	2020	lncRNA TPTEP1 competitively sponges miR‑328‑5p to inhibit the proliferation of non‑small cell lung cancer cells.	16
32924985	2020	FOXD3-AS1 suppresses the progression of non-small cell lung cancer by regulating miR-150/SRCIN1axis.	8
32964035	2020	SRCIN1 Regulated by circCCDC66/miR-211 Is Upregulated and Promotes Cell Proliferation in Non-Small-Cell Lung Cancer.	8
30302813	2019	miR-17-5p promotes proliferation and epithelial-mesenchymal transition in human osteosarcoma cells by targeting SRC kinase signaling inhibitor 1.	13
30315850	2019	MiR-150 promotes angiogensis and proliferation of endothelial progenitor cells in deep venous thrombosis by targeting SRCIN1.	19
30890278	2019	MicroRNA-374a promotes pancreatic cancer cell proliferation and epithelial to mesenchymal transition by targeting SRCIN1.	11

Citation

Dessen P

SRCIN1 (SRC kinase signaling inhibitor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-09-01

Online version: http://atlasgeneticsoncology.org/gene/49749/srcin1-(src-kinase-signaling-inhibitor-1)