Identity
HGNC
LOCATION
22q11.21
LOCUSID
ALIAS
ISG43,PTORCH2,UBP43
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 11274
MIM: 607057
HGNC: 12616
Ensembl: ENSG00000184979
Variants:
dbSNP: 11274
ClinVar: 11274
TCGA: ENSG00000184979
COSMIC: USP18
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000184979 | ENST00000215794 | Q9UMW8 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA36184 | STAT2 | Gene | Pathway | associated | 26111151 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37625543 | 2024 | ISG15-USP18 Dysregulation by Oxidative Stress Promotes IFN-γ Secretion from CD8+ T Cells in Vitiligo. | 2 |
| 38691302 | 2024 | USP18 Curbs the Progression of Metabolic Hypertension by Suppressing JAK/STAT Pathway. | 0 |
| 37625543 | 2024 | ISG15-USP18 Dysregulation by Oxidative Stress Promotes IFN-γ Secretion from CD8+ T Cells in Vitiligo. | 2 |
| 38691302 | 2024 | USP18 Curbs the Progression of Metabolic Hypertension by Suppressing JAK/STAT Pathway. | 0 |
| 36646704 | 2023 | Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis. | 18 |
| 37186433 | 2023 | UBP43 promotes epithelial ovarian carcinogenesis via activation of β-catenin signaling pathway. | 0 |
| 37257245 | 2023 | USP18 regulates the malignant phenotypes of glioblastoma stem cells. | 2 |
| 37422930 | 2023 | USP18 promotes innate immune responses and apoptosis in influenza A virus-infected A549 cells via cGAS-STING pathway. | 1 |
| 37442266 | 2023 | Tumor-promoting action of ubiquitin protease 43 in gastric cancer progression through deubiquitination and stabilization of stress-inducible phosphoprotein 1. | 0 |
| 37506491 | 2023 | Genome-wide DNA methylation analysis implicates enrichment of interferon pathway in African American patients with Systemic Lupus Erythematosus and European Americans with lupus nephritis. | 0 |
| 36646704 | 2023 | Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis. | 18 |
| 37186433 | 2023 | UBP43 promotes epithelial ovarian carcinogenesis via activation of β-catenin signaling pathway. | 0 |
| 37257245 | 2023 | USP18 regulates the malignant phenotypes of glioblastoma stem cells. | 2 |
| 37422930 | 2023 | USP18 promotes innate immune responses and apoptosis in influenza A virus-infected A549 cells via cGAS-STING pathway. | 1 |
| 37442266 | 2023 | Tumor-promoting action of ubiquitin protease 43 in gastric cancer progression through deubiquitination and stabilization of stress-inducible phosphoprotein 1. | 0 |
Citation
Dessen P
USP18 (ubiquitin specific peptidase 18)
Atlas Genet Cytogenet Oncol Haematol. 2007-10-01
Online version: http://atlasgeneticsoncology.org/gene/49760/usp18-(ubiquitin-specific-peptidase-18)
