CCT5 (chaperonin containing TCP1 subunit 5)

2007-10-01  

Identity

HGNC
CCT5
LOCATION
5p15.2
LOCUSID
22948
ALIAS
CCT-epsilon,CCTE,HEL-S-69,PNAS-102,TCP-1-epsilon
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22948
MIM: 610150
HGNC: 1618
Ensembl: ENSG00000150753

Variants:

dbSNP: 22948
ClinVar: 22948
TCGA: ENSG00000150753
COSMIC: CCT5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000150753ENST00000280326P48643
ENSG00000150753ENST00000280326V9HW37
ENSG00000150753ENST00000503026E9PCA1
ENSG00000150753ENST00000503454H0Y914
ENSG00000150753ENST00000506600P48643
ENSG00000150753ENST00000511700H0Y958
ENSG00000150753ENST00000512975D6RIZ7
ENSG00000150753ENST00000515390E7ENZ3
ENSG00000150753ENST00000515676B7ZAR1
ENSG00000150753ENST00000625723D6RIZ7

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Cooperation of Prefoldin and TriC/CCT in actin and tubulin foldingREACTOMER-HSA-389958
Prefoldin mediated transfer of substrate to CCT/TriCREACTOMER-HSA-389957
Formation of tubulin folding intermediates by CCT/TriCREACTOMER-HSA-389960
Folding of actin by CCT/TriCREACTOMER-HSA-390450
Association of TriC/CCT with target proteins during biosynthesisREACTOMER-HSA-390471
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
BBSome-mediated cargo-targeting to ciliumREACTOMER-HSA-5620922
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingREACTOMER-HSA-6814122

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
196517022009Genes for hereditary sensory and autonomic neuropathies: a genotype-phenotype correlation.41
163998792006Mutation in the epsilon subunit of the cytosolic chaperonin-containing t-complex peptide-1 (Cct5) gene causes autosomal recessive mutilating sensory neuropathy with spastic paraplegia.40
184210762008A genome-wide scan maps a novel high myopia locus to 5p15.38
204680642010Association study of 182 candidate genes in anorexia nervosa.30
236129812013Human CCT4 and CCT5 chaperonin subunits expressed in Escherichia coli form biologically active homo-oligomers.26
168210822007Possible involvement of CCT5, RGS3, and YKT6 genes up-regulated in p53-mutated tumors in resistance to docetaxel in human breast cancers.24
259954522015Structural Mechanisms of Mutant Huntingtin Aggregation Suppression by the Synthetic Chaperonin-like CCT5 Complex Explained by Cryoelectron Tomography.14
251240382014Biochemical characterization of mutants in chaperonin proteins CCT4 and CCT5 associated with hereditary sensory neuropathy.9
222322652012A novel function of the human chaperonin CCT epsilon subunit in yeast.1

Citation

Dessen P

CCT5 (chaperonin containing TCP1 subunit 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-10-01

Online version: http://atlasgeneticsoncology.org/gene/49762/cct5-(chaperonin-containing-tcp1-subunit-5)