CALCR (calcitonin receptor)

2007-10-01 Affiliation

Identity

HGNC

CALCR

LOCATION

7q21.3

LOCUSID

799

ALIAS

CRT,CT-R,CTR,CTR1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 799
MIM: 114131
HGNC: 1440
Ensembl: ENSG00000004948

Variants:

dbSNP: 799
ClinVar: 799
TCGA: ENSG00000004948
COSMIC: CALCR

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000004948	ENST00000359558	A0A0A0MRG0
ENSG00000004948	ENST00000360249	D8MIV0
ENSG00000004948	ENST00000394441	A0A0C4DG16
ENSG00000004948	ENST00000415529	P30988
ENSG00000004948	ENST00000423724	P30988
ENSG00000004948	ENST00000426151	A0A0C4DG16
ENSG00000004948	ENST00000649521	A0A0A0MSQ7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class B/2 (Secretin family receptors)	REACTOME	R-HSA-373080
Calcitonin-like ligand receptors	REACTOME	R-HSA-419812
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555

Protein levels (Protein atlas)

Not detected

Low

Medium

High

cerebral cortex

cerebellum

hippocampus

caudate

hypothalamus

thyroid gland

parathyroid gland

adrenal gland

nasopharynx

bronchus

lung

oral mucosa

salivary gland

esophagus

stomach 1

stomach 2

duodenum

small intestine

colon

rectum

liver

gallbladder

pancreas

kidney

urinary bladder

testis

epididymis

seminal vesicle

prostate

vagina

ovary

fallopian tube

endometrium 1

endometrium 2

cervix, uterine

placenta

breast

heart muscle

smooth muscle

skeletal muscle

soft tissue 1

soft tissue 2

adipose tissue

skin 1

skin 2

appendix

spleen

lymph node

tonsil

bone marrow

References

Pubmed ID	Year	Title	Citations
36834780	2023	Polymorphisms in Genes Encoding VDR, CALCR and Antioxidant Enzymes as Predictors of Bone Tissue Condition in Young, Healthy Men.	2
37543479	2023	Calcitonin/PAC(1) receptor splice variants: a blind spot in migraine research.	0
36834780	2023	Polymorphisms in Genes Encoding VDR, CALCR and Antioxidant Enzymes as Predictors of Bone Tissue Condition in Young, Healthy Men.	2
37543479	2023	Calcitonin/PAC(1) receptor splice variants: a blind spot in migraine research.	0
35090891	2022	Copper(II) import and reduction are dependent on His-Met clusters in the extracellular amino terminus of human copper transporter-1.	5
35202609	2022	Dynamical interplay between the human high-affinity copper transporter hCtr1 and its cognate metal ion.	3
36088585	2022	Association of TRPV5, CASR, and CALCR genetic variants with kidney stone disease susceptibility in Egyptians through main effects and gene-gene interactions.	2
35090891	2022	Copper(II) import and reduction are dependent on His-Met clusters in the extracellular amino terminus of human copper transporter-1.	5
35202609	2022	Dynamical interplay between the human high-affinity copper transporter hCtr1 and its cognate metal ion.	3
36088585	2022	Association of TRPV5, CASR, and CALCR genetic variants with kidney stone disease susceptibility in Egyptians through main effects and gene-gene interactions.	2
33823567	2021	Gender-Dependent Reference Range of Serum Calcitonin Levels in Healthy Korean Adults.	3
34312771	2021	Genetic Depletion of Amylin/Calcitonin Receptors Improves Memory and Learning in Transgenic Alzheimer's Disease Mouse Models.	6
34417812	2021	CALCR knockdown inhibits the development and progression of non-small-cell lung cancer.	1
33823567	2021	Gender-Dependent Reference Range of Serum Calcitonin Levels in Healthy Korean Adults.	3
34312771	2021	Genetic Depletion of Amylin/Calcitonin Receptors Improves Memory and Learning in Transgenic Alzheimer's Disease Mouse Models.	6

Citation

Dessen P

CALCR (calcitonin receptor)

Atlas Genet Cytogenet Oncol Haematol. 2007-10-01

Online version: http://atlasgeneticsoncology.org/gene/49768/tumors-explorer/meetings/hgnc