B4GALT5 (beta-1,4-galactosyltransferase 5)

2007-11-01  

Identity

HGNC
B4GALT5
LOCATION
20q13.13
LOCUSID
9334
ALIAS
B4Gal-T5,BETA4-GALT-IV,beta4Gal-T5,beta4GalT-V,gt-V
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9334
MIM: 604016
HGNC: 928
Ensembl: ENSG00000158470

Variants:

dbSNP: 9334
ClinVar: 9334
TCGA: ENSG00000158470
COSMIC: B4GALT5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158470ENST00000371711O43286

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Mucin type O-glycan biosynthesisKEGGko00512
Mucin type O-glycan biosynthesisKEGGhsa00512
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
N-glycan antennae elongation in the medial/trans-GolgiREACTOMER-HSA-975576
N-Glycan antennae elongationREACTOMER-HSA-975577
O-linked glycosylationREACTOMER-HSA-5173105
O-linked glycosylation of mucinsREACTOMER-HSA-913709
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Keratan sulfate/keratin metabolismREACTOMER-HSA-1638074
Keratan sulfate biosynthesisREACTOMER-HSA-2022854

References

Pubmed IDYearTitleCitations
237443542013B4GALT family mediates the multidrug resistance of human leukemia cells by regulating the hedgehog pathway and the expression of p-glycoprotein and multidrug resistance-associated protein 1.25
176563642007Sequential action of Ets-1 and Sp1 in the activation of the human beta-1,4-galactosyltransferase V gene involved in abnormal glycosylation characteristic of cancer cells.13
176901042007Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans.12
204176172010Beta1,4-galactosyltransferase V regulates self-renewal of glioma-initiating cell.7
164613572006Beta1,4-galactosyltransferase V functions as a positive growth regulator in glioma.6
123855862002Over-expression of beta-1,4-galactosyltransferase V increases the growth of astrocytoma cell line.5
152630122004Transcriptional regulation of the human beta-1,4-galactosyltransferase V gene in cancer cells: essential role of transcription factor Sp1.4
305020902019Lactosylceramide synthase β-1,4-GalT-V: A novel target for the diagnosis and therapy of human colorectal cancer.4
294159972018Downregulation of β1,4-galactosyltransferase 5 improves insulin resistance by promoting adipocyte commitment and reducing inflammation.2
226877272012[Regulation of human β-1,4-galactosyltransferase V gene expression in cancer cells].0

Citation

Dessen P

B4GALT5 (beta-1,4-galactosyltransferase 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-11-01

Online version: http://atlasgeneticsoncology.org/gene/49822/b4galt5-(beta-1-4-galactosyltransferase-5)