ACACB (acetyl-CoA carboxylase beta)

2007-12-01 Dessen P Affiliation

Identity

HGNC

ACACB

LOCATION

12q24.11

LOCUSID

ALIAS

ACC-beta,ACC2,ACCB,HACC275

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 32
MIM: 601557
HGNC: 85
Ensembl: ENSG00000076555

Variants:

dbSNP: 32
ClinVar: 32
TCGA: ENSG00000076555
COSMIC: ACACB

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000076555	ENST00000338432	O00763
ENSG00000076555	ENST00000377848	O00763
ENSG00000076555	ENST00000377854	F8W8T8
ENSG00000076555	ENST00000536440	A0A087WUA1
ENSG00000076555	ENST00000538526	H0YGH5
ENSG00000076555	ENST00000539864	F5H5C3
ENSG00000076555	ENST00000544726	S4R3S7

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Fatty acid biosynthesis	KEGG	ko00061
Pyruvate metabolism	KEGG	ko00620
Propanoate metabolism	KEGG	ko00640
Insulin signaling pathway	KEGG	ko04910
Adipocytokine signaling pathway	KEGG	ko04920
Fatty acid biosynthesis	KEGG	hsa00061
Pyruvate metabolism	KEGG	hsa00620
Propanoate metabolism	KEGG	hsa00640
Insulin signaling pathway	KEGG	hsa04910
Adipocytokine signaling pathway	KEGG	hsa04920
Metabolic pathways	KEGG	hsa01100
AMPK signaling pathway	KEGG	hsa04152
AMPK signaling pathway	KEGG	ko04152
Glucagon signaling pathway	KEGG	hsa04922
Glucagon signaling pathway	KEGG	ko04922
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Regulation of cholesterol biosynthesis by SREBP (SREBF)	REACTOME	R-HSA-1655829
Activation of gene expression by SREBF (SREBP)	REACTOME	R-HSA-2426168
Integration of energy metabolism	REACTOME	R-HSA-163685
ChREBP activates metabolic gene expression	REACTOME	R-HSA-163765
Metabolism of vitamins and cofactors	REACTOME	R-HSA-196854
Metabolism of water-soluble vitamins and cofactors	REACTOME	R-HSA-196849
Biotin transport and metabolism	REACTOME	R-HSA-196780
Insulin resistance	KEGG	hsa04931

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA33744	PRKAA1	Gene	Pathway	associated	22722338
PA33745	PRKAA2	Gene	Pathway	associated	22722338
PA33746	PRKAB1	Gene	Pathway	associated	22722338
PA33747	PRKAB2	Gene	Pathway	associated	22722338
PA33751	PRKAG1	Gene	Pathway	associated	22722338
PA33752	PRKAG2	Gene	Pathway	associated	22722338
PA33753	PRKAG3	Gene	Pathway	associated	22722338

References

Pubmed ID	Year	Title	Citations
34939260	2022	Acetyl-coenzyme A carboxylase beta gene polymorphism does not predict cardiovascular risk susceptibility in Chinese type 2 diabetic individuals.	1
36111743	2022	ACACB is a novel metabolism-related biomarker in the prediction of response to cetuximab therapy inmetastatic colorectal cancer.	1
34939260	2022	Acetyl-coenzyme A carboxylase beta gene polymorphism does not predict cardiovascular risk susceptibility in Chinese type 2 diabetic individuals.	1
36111743	2022	ACACB is a novel metabolism-related biomarker in the prediction of response to cetuximab therapy inmetastatic colorectal cancer.	1
33957017	2021	Faster lipid β-oxidation rate by acetyl-CoA carboxylase 2 inhibition alleviates high-glucose-induced insulin resistance via SIRT1/PGC-1α in human podocytes.	7
34085602	2021	Identification of core gene in obese type 2 diabetes patients using bioinformatics analysis.	7
33957017	2021	Faster lipid β-oxidation rate by acetyl-CoA carboxylase 2 inhibition alleviates high-glucose-induced insulin resistance via SIRT1/PGC-1α in human podocytes.	7
34085602	2021	Identification of core gene in obese type 2 diabetes patients using bioinformatics analysis.	7
29772612	2018	Activity and structure of human acetyl-CoA carboxylase targeted by a specific inhibitor.	2
29772612	2018	Activity and structure of human acetyl-CoA carboxylase targeted by a specific inhibitor.	2
27693630	2017	Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab.	43
28081256	2017	Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells.	48
28290443	2017	Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.	48
28768177	2017	Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.	136
29107296	2017	Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants.	32

Citation

Dessen P

ACACB (acetyl-CoA carboxylase beta)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49847/acacb-(acetyl-coa-carboxylase-beta)