ACBD3 (acyl-CoA binding domain containing 3)

2007-12-01  

Identity

HGNC
LOCATION
1q42.12
LOCUSID
ALIAS
GCP60,GOCAP1,GOLPH1,PAP7
FUSION GENES

Other Information

Locus ID:

NCBI: 64746
MIM: 606809
HGNC: 15453
Ensembl: ENSG00000182827

Variants:

dbSNP: 64746
ClinVar: 64746
TCGA: ENSG00000182827
COSMIC: ACBD3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182827ENST00000366812Q9H3P7
ENSG00000182827ENST00000366812A0A024R3P9

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Golgi Associated Vesicle BiogenesisREACTOMER-HSA-432722

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
222582602012The 3A protein from multiple picornaviruses utilizes the golgi adaptor protein ACBD3 to recruit PI4KIIIβ.79
221243282012ACBD3-mediated recruitment of PI4KB to picornavirus RNA replication sites.77
186361242008Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.32
246720442014A complex comprising phosphatidylinositol 4-kinase IIIβ, ACBD3, and Aichi virus proteins enhances phosphatidylinositol 4-phosphate synthesis and is critical for formation of the viral replication complex.25
239263332013The Golgi protein ACBD3, an interactor for poliovirus protein 3A, modulates poliovirus replication.23
235725522013ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding.21
240127562013Golgi protein ACBD3 mediates neurotoxicity associated with Huntington's disease.21
168706222006GCP60 preferentially interacts with a caspase-generated golgin-160 fragment.20
262882492015Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.17
279896222017The Molecular Basis of Aichi Virus 3A Protein Activation of Phosphatidylinositol 4 Kinase IIIβ, PI4KB, through ACBD3.17

Citation

Dessen P

ACBD3 (acyl-CoA binding domain containing 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49848/acbd3-(acyl-coa-binding-domain-containing-3)