C4BPA (complement component 4 binding protein alpha)

2007-12-01  

Identity

HGNC
LOCATION
1q32.2
LOCUSID
ALIAS
C4BP,PRP
FUSION GENES

Other Information

Locus ID:

NCBI: 722
MIM: 120830
HGNC: 1325
Ensembl: ENSG00000123838

Variants:

dbSNP: 722
ClinVar: 722
TCGA: ENSG00000123838
COSMIC: C4BPA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123838ENST00000367070P04003
ENSG00000123838ENST00000421786A6PVY5
ENSG00000123838ENST00000424088F2Z2V7

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Complement and coagulation cascadesKEGGhsa04610
PertussisKEGGko05133
PertussisKEGGhsa05133
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Complement cascadeREACTOMER-HSA-166658
Regulation of Complement cascadeREACTOMER-HSA-977606

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
188422942008Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.65
194943112009Clinical isolates of Streptococcus pneumoniae bind the complement inhibitor C4b-binding protein in a PspC allele-dependent fashion.41
229259282012Enolase of Streptococcus pneumoniae binds human complement inhibitor C4b-binding protein and contributes to complement evasion.33
194170802009Capturing host-pathogen interactions by protein microarrays: identification of novel streptococcal proteins binding to human fibronectin, fibrinogen, and C4BP.31
200223812010Binding of the complement inhibitor C4b-binding protein to Lyme disease Borreliae.28
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
175481102008Non-small cell lung cancer cells produce a functional set of complement factor I and its soluble cofactors.25
205322272010Human complement regulators C4b-binding protein and C1 esterase inhibitor interact with a novel outer surface protein of Borrelia recurrentis.25
219152482011Human pentraxin 3 binds to the complement regulator c4b-binding protein.24
266584642016C4b-binding protein: The good, the bad and the deadly. Novel functions of an old friend.23

Citation

Dessen P

C4BPA (complement component 4 binding protein alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49852/c4bpa-(complement-component-4-binding-protein-alpha)