DSTN (destrin, actin depolymerizing factor)

2007-12-01  

Identity

HGNC
DSTN
LOCATION
20p12.1
LOCUSID
11034
ALIAS
ACTDP,ADF,HEL32,bA462D18.2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11034
MIM: 609114
HGNC: 15750
Ensembl: ENSG00000125868

Variants:

dbSNP: 11034
ClinVar: 11034
TCGA: ENSG00000125868
COSMIC: DSTN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125868ENST00000246069P60981
ENSG00000125868ENST00000246069V9HWA6
ENSG00000125868ENST00000449141F6RFD5
ENSG00000125868ENST00000474024P60981

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
370193662023DSTN Hypomethylation Promotes Radiotherapy Resistance of Rectal Cancer by Activating the Wnt/β-Catenin Signaling Pathway.1
370193662023DSTN Hypomethylation Promotes Radiotherapy Resistance of Rectal Cancer by Activating the Wnt/β-Catenin Signaling Pathway.1
341206362021Positive natural selection of N6-methyladenosine on the RNAs of processed pseudogenes.9
341698362021ADF and cofilin-1 collaborate to promote cortical actin flow and the leader bleb-based migration of confined cells.12
345595792021The actin depolymerizing factor destrin serves as a negative feedback inhibitor of smooth muscle cell differentiation.2
341206362021Positive natural selection of N6-methyladenosine on the RNAs of processed pseudogenes.9
341698362021ADF and cofilin-1 collaborate to promote cortical actin flow and the leader bleb-based migration of confined cells.12
345595792021The actin depolymerizing factor destrin serves as a negative feedback inhibitor of smooth muscle cell differentiation.2
328789672020Destrin Contributes to Lung Adenocarcinoma Progression by Activating Wnt/β-Catenin Signaling Pathway.12
328789672020Destrin Contributes to Lung Adenocarcinoma Progression by Activating Wnt/β-Catenin Signaling Pathway.12
269969392016TIRF microscopy analysis of human Cof1, Cof2, and ADF effects on actin filament severing and turnover.31
269969392016TIRF microscopy analysis of human Cof1, Cof2, and ADF effects on actin filament severing and turnover.31
228986372012The actin binding protein destrin is associated with growth and perineural invasion of pancreatic cancer.9
228986372012The actin binding protein destrin is associated with growth and perineural invasion of pancreatic cancer.9
215712222011ADF/cofilin regulates secretory cargo sorting at the TGN via the Ca2+ ATPase SPCA1.57

Citation

Dessen P

DSTN (destrin, actin depolymerizing factor)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49860/dstn-(destrin-actin-depolymerizing-factor)