KLC1 (kinesin light chain 1)

2007-12-01 Affiliation

Identity

HGNC

KLC1

LOCATION

14q32.33

LOCUSID

3831

ALIAS

KLC,KNS2,KNS2A

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3831
MIM: 600025
HGNC: 6387
Ensembl: ENSG00000126214

Variants:

dbSNP: 3831
ClinVar: 3831
TCGA: ENSG00000126214
COSMIC: KLC1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000126214	ENST00000246489	Q07866
ENSG00000126214	ENST00000334553	Q07866
ENSG00000126214	ENST00000347839	Q07866
ENSG00000126214	ENST00000348520	Q07866
ENSG00000126214	ENST00000380038	F8W6L3
ENSG00000126214	ENST00000389744	Q07866
ENSG00000126214	ENST00000445352	G5E9S8
ENSG00000126214	ENST00000452929	Q07866
ENSG00000126214	ENST00000535194	H0YGB8
ENSG00000126214	ENST00000537046	H0YG16
ENSG00000126214	ENST00000553286	Q07866
ENSG00000126214	ENST00000553325	H0YJU9
ENSG00000126214	ENST00000553436	H0YJT3
ENSG00000126214	ENST00000554228	Q07866
ENSG00000126214	ENST00000554280	G3V3H3
ENSG00000126214	ENST00000555836	G3V5R9
ENSG00000126214	ENST00000555856	H0YJL0
ENSG00000126214	ENST00000557172	G3V2P7
ENSG00000126214	ENST00000557450	Q07866
ENSG00000126214	ENST00000557575	G3V2E7
ENSG00000126214	ENST00000557686	H0YJK1
ENSG00000126214	ENST00000634686	Q07866

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Salmonella infection	KEGG	ko05132
Salmonella infection	KEGG	hsa05132
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
MHC class II antigen presentation	REACTOME	R-HSA-2132295
Hemostasis	REACTOME	R-HSA-109582
Factors involved in megakaryocyte development and platelet production	REACTOME	R-HSA-983231
Kinesins	REACTOME	R-HSA-983189
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Rho GTPases	REACTOME	R-HSA-194315
RHO GTPase Effectors	REACTOME	R-HSA-195258
RHO GTPases activate KTN1	REACTOME	R-HSA-5625970
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER traffic	REACTOME	R-HSA-6811442
Golgi-to-ER retrograde transport	REACTOME	R-HSA-8856688
COPI-dependent Golgi-to-ER retrograde traffic	REACTOME	R-HSA-6811434

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA128406956	fluorouracil	Chemical	ClinicalAnnotation	associated	PD	17549067
PA446108	Colorectal Neoplasms	Disease	ClinicalAnnotation	associated	PD	17549067
PA450085	irinotecan	Chemical	ClinicalAnnotation	associated	PD	17549067
PA450198	leucovorin	Chemical	ClinicalAnnotation	associated	PD	17549067

References

Pubmed ID	Year	Title	Citations
38768546	2024	Gene-gene functional relationships in Alzheimer's disease: CELF1 regulates KLC1 alternative splicing.	0
38768546	2024	Gene-gene functional relationships in Alzheimer's disease: CELF1 regulates KLC1 alternative splicing.	0
33691783	2021	Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport.	3
33691783	2021	Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport.	3
31068217	2019	LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer's disease brains.	12
31204277	2019	A role for kinesin-1 subunits KIF5B/KLC1 in regulating epithelial mesenchymal plasticity in breast tumorigenesis.	12
31806024	2019	Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein.	19
31068217	2019	LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer's disease brains.	12
31204277	2019	A role for kinesin-1 subunits KIF5B/KLC1 in regulating epithelial mesenchymal plasticity in breast tumorigenesis.	12
31806024	2019	Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein.	19
29445114	2018	Kinesin 1 regulates cilia length through an interaction with the Bardet-Biedl syndrome related protein CCDC28B.	12
30026235	2018	Characterization of the binding mode of JNK-interacting protein 1 (JIP1) to kinesin-light chain 1 (KLC1).	3
29445114	2018	Kinesin 1 regulates cilia length through an interaction with the Bardet-Biedl syndrome related protein CCDC28B.	12
30026235	2018	Characterization of the binding mode of JNK-interacting protein 1 (JIP1) to kinesin-light chain 1 (KLC1).	3
27891669	2017	A molecular dynamics study of the binary complexes of APP, JIP1, and the cargo binding domain of KLC.	2

Citation

Dessen P

KLC1 (kinesin light chain 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49869/klc1-(kinesin-light-chain-1)