Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7054
MIM: 191290
HGNC: 11782
Ensembl: ENSG00000180176
Variants:
dbSNP: 7054
ClinVar: 7054
TCGA: ENSG00000180176
COSMIC: TH
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA445043 | Opioid-Related Disorders | Disease | ClinicalAnnotation | associated | PD | 29210332, 32232669 | |
| PA447197 | Attention Deficit Disorder with Hyperactivity | Disease | ClinicalAnnotation | associated | PD | 26810137 | |
| PA450464 | methylphenidate | Chemical | ClinicalAnnotation | associated | PD | 26810137 | |
| PA450487 | metyrosine | Chemical | Pathway | associated | |||
| PA452618 | opioids | Chemical | ClinicalAnnotation | associated | PD | 29210332, 32232669 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37624484 | 2024 | Association of tyrosine hydroxylase 01 (TH01) microsatellite and insulin gene (INS) variable number of tandem repeat (VNTR) with type 2 diabetes and fasting insulin secretion in Mexican population. | 1 |
| 38084654 | 2024 | Tyrosine hydroxylase variants influence protein expression, cellular localization, stability, enzymatic activity and the physical interaction between tyrosine hydroxylase and GTP cyclohydrolase 1. | 0 |
| 37624484 | 2024 | Association of tyrosine hydroxylase 01 (TH01) microsatellite and insulin gene (INS) variable number of tandem repeat (VNTR) with type 2 diabetes and fasting insulin secretion in Mexican population. | 1 |
| 38084654 | 2024 | Tyrosine hydroxylase variants influence protein expression, cellular localization, stability, enzymatic activity and the physical interaction between tyrosine hydroxylase and GTP cyclohydrolase 1. | 0 |
| 37011980 | 2023 | [Clinical and genetic characteristics of children with dopa-responsive dystonia caused by tyrosine hydroxylase gene variations]. | 0 |
| 37840187 | 2023 | [Clinical and genetic analysis of tyrosine hydroxylase deficiency of six cases]. | 0 |
| 37011980 | 2023 | [Clinical and genetic characteristics of children with dopa-responsive dystonia caused by tyrosine hydroxylase gene variations]. | 0 |
| 37840187 | 2023 | [Clinical and genetic analysis of tyrosine hydroxylase deficiency of six cases]. | 0 |
| 34922205 | 2022 | Tyrosine hydroxylase activity is regulated through the modification of the 176th cysteine residue. | 1 |
| 35013193 | 2022 | Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. | 13 |
| 35258801 | 2022 | Expression Quantitative Trait Locus rs6356 Is Associated with Susceptibility to Heroin Addiction by Potentially Influencing TH Gene Expression in the Hippocampus and Nucleus Accumbens. | 1 |
| 36115503 | 2022 | Aging accentuates decrease in tyrosine hydroxylase immunoreactivity associated with the increase in the motor impairment in a model of reserpine-induced parkinsonism. | 1 |
| 34922205 | 2022 | Tyrosine hydroxylase activity is regulated through the modification of the 176th cysteine residue. | 1 |
| 35013193 | 2022 | Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. | 13 |
| 35258801 | 2022 | Expression Quantitative Trait Locus rs6356 Is Associated with Susceptibility to Heroin Addiction by Potentially Influencing TH Gene Expression in the Hippocampus and Nucleus Accumbens. | 1 |
Citation
Dessen P
TH (tyrosine hydroxylase)
Atlas Genet Cytogenet Oncol Haematol. 2007-12-01
Online version: http://atlasgeneticsoncology.org/gene/49894/th-(tyrosine-hydroxylase)
