ULBP2 (UL16 binding protein 2)

2007-12-01  

Identity

HGNC
ULBP2
LOCATION
6q25.1
LOCUSID
80328
ALIAS
ALCAN-alpha,N2DL2,NKG2DL2,RAET1H,RAET1L
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80328
MIM: 605698
HGNC: 14894
Ensembl: ENSG00000131015

Variants:

dbSNP: 80328
ClinVar: 80328
TCGA: ENSG00000131015
COSMIC: ULBP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131015ENST00000367351Q9BZM5

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Natural killer cell mediated cytotoxicityKEGGko04650
Natural killer cell mediated cytotoxicityKEGGhsa04650
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteinsREACTOMER-HSA-163125

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
377744962024Upregulation of the NKG2D Ligand ULBP2 by JC Polyomavirus Infection Promotes Immune Recognition by Natural Killer Cells.0
377744962024Upregulation of the NKG2D Ligand ULBP2 by JC Polyomavirus Infection Promotes Immune Recognition by Natural Killer Cells.0
366338272023ULBP2 is a biomarker related to prognosis and immunity in colon cancer.1
366338272023ULBP2 is a biomarker related to prognosis and immunity in colon cancer.1
319021102020MiR-873, as a suppressor in cervical cancer, inhibits cells proliferation, invasion and migration via negatively regulating ULBP2.10
321441612020Fumarate Upregulates Surface Expression of ULBP2/ULBP5 by Scavenging Glutathione Antioxidant Capacity.1
326059222020Staphylococcus aureus induces cell-surface expression of immune stimulatory NKG2D ligands on human monocytes.6
319021102020MiR-873, as a suppressor in cervical cancer, inhibits cells proliferation, invasion and migration via negatively regulating ULBP2.10
321441612020Fumarate Upregulates Surface Expression of ULBP2/ULBP5 by Scavenging Glutathione Antioxidant Capacity.1
326059222020Staphylococcus aureus induces cell-surface expression of immune stimulatory NKG2D ligands on human monocytes.6
308139242019Natural killer group 2D receptor and its ligands in cancer immune escape.111
313032722019Soluble UL16-binding protein 2 is associated with a poor prognosis in pancreatic cancer patients.10
308139242019Natural killer group 2D receptor and its ligands in cancer immune escape.111
313032722019Soluble UL16-binding protein 2 is associated with a poor prognosis in pancreatic cancer patients.10
296363902018A nanoscale reorganization of the IL-15 receptor is triggered by NKG2D in a ligand-dependent manner.16

Citation

Dessen P

ULBP2 (UL16 binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49898/ulbp2-(ul16-binding-protein-2)