PTPN5 (protein tyrosine phosphatase non-receptor type 5)

2007-12-01  

Identity

HGNC
PTPN5
LOCATION
11p15.1
LOCUSID
84867
ALIAS
PTPSTEP,STEP,STEP61

Other Information

Locus ID:

NCBI: 84867
MIM: 176879
HGNC: 9657
Ensembl: ENSG00000110786

Variants:

dbSNP: 84867
ClinVar: 84867
TCGA: ENSG00000110786
COSMIC: PTPN5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110786ENST00000358540P54829
ENSG00000110786ENST00000396166A8MXF1
ENSG00000110786ENST00000396168P54829
ENSG00000110786ENST00000396170P54829
ENSG00000110786ENST00000477854E9PLZ4

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366397082023Tyrosine phosphatase STEP(61) in human dementia and in animal models with amyloid and tau pathology.1
366397082023Tyrosine phosphatase STEP(61) in human dementia and in animal models with amyloid and tau pathology.1
342708052021PTPN5 promotes follicle-stimulating hormone secretion through regulating intracellular calcium homeostasis.3
342708052021PTPN5 promotes follicle-stimulating hormone secretion through regulating intracellular calcium homeostasis.3
324611272020Inhibition of striatal-enriched protein tyrosine phosphatase (STEP) activity reverses behavioral deficits in a rodent model of autism.1
324611272020Inhibition of striatal-enriched protein tyrosine phosphatase (STEP) activity reverses behavioral deficits in a rodent model of autism.1
311350412019Loss of STEP61 couples disinhibition to N-methyl-d-aspartate receptor potentiation in rodent and human spinal pain processing.33
311350412019Loss of STEP61 couples disinhibition to N-methyl-d-aspartate receptor potentiation in rodent and human spinal pain processing.33
283893752017Striatal-enriched phosphatase 61 inhibited the nociceptive plasticity in spinal cord dorsal horn of rats.2
285286952017Protein phosphatase 5 promotes hepatocarcinogenesis through interaction with AMP-activated protein kinase.12
286752972017A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.9
286995112017Striatal-enriched Tyrosine Protein Phosphatase (STEP) in the Mechanisms of Depressive Disorders.11
283893752017Striatal-enriched phosphatase 61 inhibited the nociceptive plasticity in spinal cord dorsal horn of rats.2
285286952017Protein phosphatase 5 promotes hepatocarcinogenesis through interaction with AMP-activated protein kinase.12
286752972017A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.9

Citation

Dessen P

PTPN5 (protein tyrosine phosphatase non-receptor type 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49904/ptpn5-(protein-tyrosine-phosphatase-non-receptor-type-5)