AFAP1 (actin filament associated protein 1)

2007-12-01  

Identity

HGNC
AFAP1
LOCATION
4p16.1
LOCUSID
60312
ALIAS
AFAP,AFAP-110,AFAP110
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 60312
MIM: 608252
HGNC: 24017
Ensembl: ENSG00000196526

Variants:

dbSNP: 60312
ClinVar: 60312
TCGA: ENSG00000196526
COSMIC: AFAP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196526ENST00000358461Q8N556
ENSG00000196526ENST00000360265Q8N556
ENSG00000196526ENST00000382543Q8N556
ENSG00000196526ENST00000420658Q8N556
ENSG00000196526ENST00000614385A0A087X177

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
233337112013Hypomethylation of noncoding DNA regions and overexpression of the long noncoding RNA, AFAP1-AS1, in Barrett's esophagus and esophageal adenocarcinoma.91
251731052014Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma.63
303269302018Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of miR-423-5p to facilitate nasopharyngeal carcinoma metastasis through regulating the Rho/Rac pathway.40
175206952007AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells.24
296541692018LncRNA AFAP1-AS1 is a prognostic biomarker and serves as oncogenic role in retinoblastoma.7
294393132018Expression analysis of AFAP1-AS1 and AFAP1 in breast cancer.6
281124072017Actin filament-associated protein 1 (AFAP-1) is a key mediator in inflammatory signaling-induced rapid attenuation of intrinsic P-gp function in human brain capillary endothelial cells.5
278620862017Correlations of AFAP1, GMDS and PTGFR gene polymorphisms with intra-ocular pressure response to latanoprost in patients with primary open-angle glaucoma.1
295447482018The prognostic value of high LncRNA AFAP1-AS1 expression in various cancers: A systematic review and meta-analysis containing 21 studies.1
318754362019[Expression and functions of long non-coding RNA actin filament-associated protein 1-antisense RNA1 in oral squamous cell carcinoma].0

Citation

Dessen P

AFAP1 (actin filament associated protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49918/afap1-(actin-filament-associated-protein-1)