NOX3 (NADPH oxidase 3)

2007-12-01 Affiliation

Identity

HGNC

NOX3

LOCATION

6q25.3

LOCUSID

50508

ALIAS

GP91-3,MOX-2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 50508
MIM: 607105
HGNC: 7890
Ensembl: ENSG00000074771

Variants:

dbSNP: 50508
ClinVar: 50508
TCGA: ENSG00000074771
COSMIC: NOX3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000074771	ENST00000159060	Q9HBY0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Leukocyte transendothelial migration	KEGG	ko04670
Leukocyte transendothelial migration	KEGG	hsa04670
NOD-like receptor signaling pathway	KEGG	ko04621
NOD-like receptor signaling pathway	KEGG	hsa04621
Phagosome	KEGG	ko04145
Phagosome	KEGG	hsa04145
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
HIF-1 signaling pathway	KEGG	hsa04066
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Rho GTPases	REACTOME	R-HSA-194315
RHO GTPase Effectors	REACTOME	R-HSA-195258
RHO GTPases Activate NADPH Oxidases	REACTOME	R-HSA-5668599
AGE-RAGE signaling pathway in diabetic complications	KEGG	ko04933
AGE-RAGE signaling pathway in diabetic complications	KEGG	hsa04933
Fluid shear stress and atherosclerosis	KEGG	ko05418
Fluid shear stress and atherosclerosis	KEGG	hsa05418

References

Pubmed ID	Year	Title	Citations
32014026	2020	Associations of noise kurtosis, genetic variations in NOX3 and lifestyle factors with noise-induced hearing loss.	7
32014026	2020	Associations of noise kurtosis, genetic variations in NOX3 and lifestyle factors with noise-induced hearing loss.	7
30290780	2018	Genome-wide association study identifies loci and candidate genes for non-idiopathic pulmonary hypertension in Eastern Chinese Han population.	9
30290780	2018	Genome-wide association study identifies loci and candidate genes for non-idiopathic pulmonary hypertension in Eastern Chinese Han population.	9
28486791	2017	Rare NOX3 Variants Confer Susceptibility to Agranulocytosis During Thyrostatic Treatment of Graves' Disease.	6
28486791	2017	Rare NOX3 Variants Confer Susceptibility to Agranulocytosis During Thyrostatic Treatment of Graves' Disease.	6
25439478	2015	Oxidant stress regulatory genetic variation in recipients and donors contributes to risk of primary graft dysfunction after lung transplantation.	17
25439478	2015	Oxidant stress regulatory genetic variation in recipients and donors contributes to risk of primary graft dysfunction after lung transplantation.	17
21901141	2011	Impaired OXPHOS complex III in breast cancer.	58
21901141	2011	Impaired OXPHOS complex III in breast cancer.	58
20056178	2010	Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.	6
20102709	2010	NOX3-derived reactive oxygen species promote TNF-alpha-induced reductions in hepatocyte glycogen levels via a JNK pathway.	20
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	15
20647313	2010	The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways.	120
20056178	2010	Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.	6

Citation

Dessen P

NOX3 (NADPH oxidase 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49920/nox3-(nadph-oxidase-3)