CUL7 (cullin 7)

2007-12-01  

Identity

HGNC
CUL7
LOCATION
6p21.1
LOCUSID
9820
ALIAS
3M1,CUL-7,KIAA0076,dJ20C7.5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9820
MIM: 609577
HGNC: 21024
Ensembl: ENSG00000044090

Variants:

dbSNP: 9820
ClinVar: 9820
TCGA: ENSG00000044090
COSMIC: CUL7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000044090ENST00000265348Q14999
ENSG00000044090ENST00000535468Q14999

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
363044722022Identification and verification of the prognostic value of CUL7 in colon adenocarcinoma.0
363044722022Identification and verification of the prognostic value of CUL7 in colon adenocarcinoma.0
332582892021A rare cause of syndromic short stature: 3M syndrome in three families.4
345978592021Natural history of facial and skeletal features from neonatal period to adulthood in a 3M syndrome cohort with biallelic CUL7 or OBSL1 variants.2
332582892021A rare cause of syndromic short stature: 3M syndrome in three families.4
345978592021Natural history of facial and skeletal features from neonatal period to adulthood in a 3M syndrome cohort with biallelic CUL7 or OBSL1 variants.2
318982342020Cullin-RING E3 Ubiquitin Ligase 7 in Growth Control and Cancer.11
321416542020Identification of two CUL7 variants in two Chinese families with 3-M syndrome by whole-exome sequencing.2
322528022020Cullin-7 (CUL7) is overexpressed in glioma cells and promotes tumorigenesis via NF-κB activation.30
322786982020A novel mutation within intron 17 of the CUL7 gene results in appearance of premature termination codon.2
318982342020Cullin-RING E3 Ubiquitin Ligase 7 in Growth Control and Cancer.11
321416542020Identification of two CUL7 variants in two Chinese families with 3-M syndrome by whole-exome sequencing.2
322528022020Cullin-7 (CUL7) is overexpressed in glioma cells and promotes tumorigenesis via NF-κB activation.30
322786982020A novel mutation within intron 17 of the CUL7 gene results in appearance of premature termination codon.2
308076462019CUL7 promotes cancer cell survival through promoting Caspase-8 ubiquitination.13

Citation

Dessen P

CUL7 (cullin 7)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49921/cul7-(cullin-7)