GRAP2 (GRB2 related adaptor protein 2)

2007-12-01  

Identity

HGNC
LOCATION
22q13.1
LOCUSID
ALIAS
GADS,GRAP-2,GRB2L,GRBLG,GRID,GRPL,GrbX,Grf40,Mona,P38
FUSION GENES

Other Information

Locus ID:

NCBI: 9402
MIM: 604518
HGNC: 4563
Ensembl: ENSG00000100351

Variants:

dbSNP: 9402
ClinVar: 9402
TCGA: ENSG00000100351
COSMIC: GRAP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100351ENST00000344138O75791
ENSG00000100351ENST00000344138Q6FI14
ENSG00000100351ENST00000407075O75791
ENSG00000100351ENST00000407075Q6FI14
ENSG00000100351ENST00000420971B1AH86

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
T cell receptor signaling pathwayKEGGko04660
T cell receptor signaling pathwayKEGGhsa04660
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
TCR signalingREACTOMER-HSA-202403
Generation of second messenger moleculesREACTOMER-HSA-202433
Costimulation by the CD28 familyREACTOMER-HSA-388841
CD28 co-stimulationREACTOMER-HSA-389356
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
FCERI mediated MAPK activationREACTOMER-HSA-2871796
FCERI mediated Ca+2 mobilizationREACTOMER-HSA-2871809
Signal TransductionREACTOMER-HSA-162582
Signaling by SCF-KITREACTOMER-HSA-1433557

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
168187652006Grb2 and Gads exhibit different interactions with CD28 and play distinct roles in CD28-mediated costimulation.20
150637622004Genetic variations in humans associated with differences in the course of hepatitis C.16
172352832007Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif.16
182955962008CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription.8
282890742017T Cell Costimulation by CD6 Is Dependent on Bivalent Binding of a GADS/SLP-76 Complex.7
200794312010The Bcr-Abl kinase regulates the actin cytoskeleton via a GADS/Slp-76/Nck1 adaptor protein pathway.6
256362002015GADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cells.6
190272252009Expression of the Grb2-related RET adapter protein Grap-2 in human medullary thyroid carcinoma.4

Citation

Dessen P

GRAP2 (GRB2 related adaptor protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49932/grap2-(grb2-related-adaptor-protein-2)