PLEKHO1 (pleckstrin homology domain containing O1)

2007-12-01  

Identity

HGNC
PLEKHO1
LOCATION
1q21.2
LOCUSID
51177
ALIAS
CKIP-1,CKIP1,JBP,OC120
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51177
MIM: 608335
HGNC: 24310
Ensembl: ENSG00000023902

Variants:

dbSNP: 51177
ClinVar: 51177
TCGA: ENSG00000023902
COSMIC: PLEKHO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000023902ENST00000369124Q53GL0
ENSG00000023902ENST00000369126Q5T4P9

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
376686842024Associations of CKIP-1 and LOX-1 polymorphisms with the risk of type 2 diabetes mellitus with hypertension among Chinese adults.0
376686842024Associations of CKIP-1 and LOX-1 polymorphisms with the risk of type 2 diabetes mellitus with hypertension among Chinese adults.0
366310362023[Effect of CKIP-1 on hepatocyte apoptosis in nonalcoholic fatty liver disease].0
373518172023CKIP-1 Promotes P. gingivalis-Induced Inflammation of Periodontal Soft Tissues by Inhibiting Autophagy.0
366310362023[Effect of CKIP-1 on hepatocyte apoptosis in nonalcoholic fatty liver disease].0
373518172023CKIP-1 Promotes P. gingivalis-Induced Inflammation of Periodontal Soft Tissues by Inhibiting Autophagy.0
322236712020High expression of the CKIP-1 gene might promote apoptosis through downregulation of the Ras/ERK signalling pathway in the intestinal type of gastric cancer.1
322236712020High expression of the CKIP-1 gene might promote apoptosis through downregulation of the Ras/ERK signalling pathway in the intestinal type of gastric cancer.1
298527992019CKIP-1 suppresses odontoblastic differentiation of dental pulp stem cells via BMP2 pathway and can interact with NRP1.4
310824892019Physiological functions of CKIP-1: From molecular mechanisms to therapy implications.11
311805212019PLEKHO1 knockdown inhibits RCC cell viability in vitro and in vivo, potentially by the Hippo and MAPK/JNK pathways.7
313552682019Casein Kinase 2 Interacting Protein-1 Suppresses Glioma Cell Proliferation via Regulating the AKT/GSK3β/β-Catenin Pathway.2
298527992019CKIP-1 suppresses odontoblastic differentiation of dental pulp stem cells via BMP2 pathway and can interact with NRP1.4
310824892019Physiological functions of CKIP-1: From molecular mechanisms to therapy implications.11
311805212019PLEKHO1 knockdown inhibits RCC cell viability in vitro and in vivo, potentially by the Hippo and MAPK/JNK pathways.7

Citation

Dessen P

PLEKHO1 (pleckstrin homology domain containing O1)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49933/plekho1-(pleckstrin-homology-domain-containing-o1)