PRMT1 (protein arginine methyltransferase 1)

2007-12-01  

Identity

HGNC
PRMT1
LOCATION
19q13.33
LOCUSID
3276
ALIAS
ANM1,HCP1,HRMT1L2,IR1B4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3276
MIM: 602950
HGNC: 5187
Ensembl: ENSG00000126457

Variants:

dbSNP: 3276
ClinVar: 3276
TCGA: ENSG00000126457
COSMIC: PRMT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126457ENST00000391851Q99873
ENSG00000126457ENST00000454376Q99873
ENSG00000126457ENST00000524771H0YDE4
ENSG00000126457ENST00000526224E9PNR9
ENSG00000126457ENST00000527382E9PQ98
ENSG00000126457ENST00000528623E9PMZ2
ENSG00000126457ENST00000529284E9PNR9
ENSG00000126457ENST00000529836E9PMW9
ENSG00000126457ENST00000532489E9PKG1
ENSG00000126457ENST00000534280E9PIE2
ENSG00000126457ENST00000534465E9PIX6
ENSG00000126457ENST00000610806Q99873

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
FoxO signaling pathwayKEGGhsa04068
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
RMTs methylate histone argininesREACTOMER-HSA-3214858
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle ArrestREACTOMER-HSA-6804114

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383839642024PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer.0
384011212024PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity.0
384022022024PRMT1-mediated PGK1 arginine methylation promotes colorectal cancer glycolysis and tumorigenesis.0
384605172024PRMT1 promotes pancreatic cancer development and resistance to chemotherapy.0
384741972024Inhibition of PRMT1 Suppresses the Growth of U87MG-Derived Glioblastoma Stem Cells by Blocking the STAT3 Signaling Pathway.0
386052142024LPCAT2 inhibits colorectal cancer progression via the PRMT1/SLC7A11 axis.2
388397522024FBXO7 ubiquitinates PRMT1 to suppress serine synthesis and tumor growth in hepatocellular carcinoma.0
390229842024Oligomerization of protein arginine methyltransferase 1 and its effect on methyltransferase activity and substrate specificity.1
383839642024PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer.0
384011212024PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity.0
384022022024PRMT1-mediated PGK1 arginine methylation promotes colorectal cancer glycolysis and tumorigenesis.0
384605172024PRMT1 promotes pancreatic cancer development and resistance to chemotherapy.0
384741972024Inhibition of PRMT1 Suppresses the Growth of U87MG-Derived Glioblastoma Stem Cells by Blocking the STAT3 Signaling Pathway.0
386052142024LPCAT2 inhibits colorectal cancer progression via the PRMT1/SLC7A11 axis.2
388397522024FBXO7 ubiquitinates PRMT1 to suppress serine synthesis and tumor growth in hepatocellular carcinoma.0

Citation

Dessen P

PRMT1 (protein arginine methyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49941/prmt1-(protein-arginine-methyltransferase-1)