The SLC6A4 gene encodes a sodium-dependent serotonin reuptake protein delivering the neurotransmitter serotonin from the synaptic cleft back to the presynaptic end. Its main function is to abort the activity of serotonin and forward it to neurotransmitter pool for recycling. The psychomotor stimulant drugs mainly amphetamines and cocaine act on this transmembrane protein which is a member of the sodium: neurotransmitter symporter family. SLC6A4 gene polymorphisms affect the rate of serotonin reuptake and play an important role in pathogenesis of various illnesses like Sudden infant death syndrome, aggressive behaviour in Alzheimer patients, Seasonal affective disorder, Major depressive Disorder and Obsessive-compulsive disorder.
NCBI: 6532 MIM: 182138 HGNC: 11050 Ensembl: ENSG00000108576
dbSNP: 6532 ClinVar: 6532 TCGA: ENSG00000108576 COSMIC: SLC6A4
Rafig Gurbanov ; Berkay Kalkanci
SLC6A4 (solute carrier family 6 member 4)
Atlas Genet Cytogenet Oncol Haematol. 2019-03-01
Online version: http://atlasgeneticsoncology.org/gene/49951/css/lib/css/gene-explorer/