BACH1 (BTB domain and CNC homolog 1)

2008-01-01  

Identity

HGNC
BACH1
LOCATION
21q21.3
LOCUSID
571
ALIAS
BACH-1,BTBD24
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 571
MIM: 602751
HGNC: 935
Ensembl: ENSG00000156273

Variants:

dbSNP: 571
ClinVar: 571
TCGA: ENSG00000156273
COSMIC: BACH1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156273ENST00000286800O14867
ENSG00000156273ENST00000399921O14867
ENSG00000156273ENST00000422809H7C4B6
ENSG00000156273ENST00000435072C9IYH8
ENSG00000156273ENST00000447177C9JMP6
ENSG00000156273ENST00000451655C9IYR0
ENSG00000156273ENST00000468059M0QZP0
ENSG00000156273ENST00000546469F8VZL7
ENSG00000156273ENST00000547141F8VZL7
ENSG00000156273ENST00000548219F8VZL7
ENSG00000156273ENST00000548467F8VZL7
ENSG00000156273ENST00000550131F8VZL7

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164925725Toxic liver diseaseDiseaseClinicalAnnotationassociatedPD22341855, 29036176
PA166119041drug-induced liver injuryDiseaseClinicalAnnotationassociatedPD22341855, 29036176
PA450112isoniazidChemicalClinicalAnnotationassociatedPD22341855, 29036176

References

Pubmed IDYearTitleCitations
386737282024TANK Binding Kinase 1 Promotes BACH1 Degradation through Both Phosphorylation-Dependent and -Independent Mechanisms without Relying on Heme and FBXO22.0
386737282024TANK Binding Kinase 1 Promotes BACH1 Degradation through Both Phosphorylation-Dependent and -Independent Mechanisms without Relying on Heme and FBXO22.0
361780672023BACH1 promotes clear cell renal cell carcinoma progression by upregulating oxidative stress-related tumorigenicity.7
364530192023Ryanodine receptor 2 promotes colorectal cancer metastasis by the ROS/BACH1 axis.3
366701122023BACH1-induced ferroptosis drives lymphatic metastasis by repressing the biosynthesis of monounsaturated fatty acids.0
367745062023FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.4
368647602023BACH1 deficiency prevents neointima formation and maintains the differentiated phenotype of vascular smooth muscle cells by regulating chromatin accessibility.5
370101332023Evaluation of Bach1 mRNA expression in patients with chronic kidney disease: A preliminary study.0
370943562023Ferroptosis model system by the re-expression of BACH1.6
371040682023Thioredoxin facilitates hepatocellular carcinoma stemness and metastasis by increasing BACH1 stability to activate the AKT/mTOR pathway.1
373115712023BACH1 promotes lung adenocarcinoma cell metastasis through transcriptional activation of ITGA2.0
374610192023Chemotherapy-induced exosomal circBACH1 promotes breast cancer resistance and stemness via miR-217/G3BP2 signaling pathway.5
376029662023Knockdown of Bach1 protects periodontal bone regeneration from inflammatory damage.2
376512032023Antioxidants stimulate BACH1-dependent tumor angiogenesis.2
379951782023BACH1 regulates the differentiation of vascular smooth muscle cells from human embryonic stem cells via CARM1-mediated methylation of H3R17.0

Citation

Dessen P

BACH1 (BTB domain and CNC homolog 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-01-01

Online version: http://atlasgeneticsoncology.org/gene/49965/bach1-(btb-domain-and-cnc-homolog-1)