BACH1 (BTB domain and CNC homolog 1)

2008-01-01  

Identity

HGNC
LOCATION
21q21.3
LOCUSID
ALIAS
BACH-1,BTBD24
FUSION GENES

Other Information

Locus ID:

NCBI: 571
MIM: 602751
HGNC: 935
Ensembl: ENSG00000156273

Variants:

dbSNP: 571
ClinVar: 571
TCGA: ENSG00000156273
COSMIC: BACH1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156273ENST00000286800O14867
ENSG00000156273ENST00000399921O14867
ENSG00000156273ENST00000422809H7C4B6
ENSG00000156273ENST00000435072C9IYH8
ENSG00000156273ENST00000447177C9JMP6
ENSG00000156273ENST00000451655C9IYR0
ENSG00000156273ENST00000468059M0QZP0
ENSG00000156273ENST00000546469F8VZL7
ENSG00000156273ENST00000547141F8VZL7
ENSG00000156273ENST00000548219F8VZL7
ENSG00000156273ENST00000548467F8VZL7
ENSG00000156273ENST00000550131F8VZL7

Expression (GTEx)

0
5
10
15
20
25
30

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164925725Toxic liver diseaseDiseaseClinicalAnnotationassociatedPD22341855, 29036176
PA166119041drug-induced liver injuryDiseaseClinicalAnnotationassociatedPD22341855, 29036176
PA450112isoniazidChemicalClinicalAnnotationassociatedPD22341855, 29036176

References

Pubmed IDYearTitleCitations
386737282024TANK Binding Kinase 1 Promotes BACH1 Degradation through Both Phosphorylation-Dependent and -Independent Mechanisms without Relying on Heme and FBXO22.0
386737282024TANK Binding Kinase 1 Promotes BACH1 Degradation through Both Phosphorylation-Dependent and -Independent Mechanisms without Relying on Heme and FBXO22.0
361780672023BACH1 promotes clear cell renal cell carcinoma progression by upregulating oxidative stress-related tumorigenicity.7
364530192023Ryanodine receptor 2 promotes colorectal cancer metastasis by the ROS/BACH1 axis.3
366701122023BACH1-induced ferroptosis drives lymphatic metastasis by repressing the biosynthesis of monounsaturated fatty acids.0
367745062023FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.4
368647602023BACH1 deficiency prevents neointima formation and maintains the differentiated phenotype of vascular smooth muscle cells by regulating chromatin accessibility.5
370101332023Evaluation of Bach1 mRNA expression in patients with chronic kidney disease: A preliminary study.0
370943562023Ferroptosis model system by the re-expression of BACH1.6
371040682023Thioredoxin facilitates hepatocellular carcinoma stemness and metastasis by increasing BACH1 stability to activate the AKT/mTOR pathway.1
373115712023BACH1 promotes lung adenocarcinoma cell metastasis through transcriptional activation of ITGA2.0
374610192023Chemotherapy-induced exosomal circBACH1 promotes breast cancer resistance and stemness via miR-217/G3BP2 signaling pathway.5
376029662023Knockdown of Bach1 protects periodontal bone regeneration from inflammatory damage.2
376512032023Antioxidants stimulate BACH1-dependent tumor angiogenesis.2
379951782023BACH1 regulates the differentiation of vascular smooth muscle cells from human embryonic stem cells via CARM1-mediated methylation of H3R17.0

Citation

Dessen P

BACH1 (BTB domain and CNC homolog 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-01-01

Online version: http://atlasgeneticsoncology.org/gene/49965/bach1-(btb-domain-and-cnc-homolog-1)