BACH1 (BTB domain and CNC homolog 1)

2008-01-01 Affiliation

Identity

HGNC

BACH1

LOCATION

21q21.3

LOCUSID

571

ALIAS

BACH-1,BTBD24

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 571
MIM: 602751
HGNC: 935
Ensembl: ENSG00000156273

Variants:

dbSNP: 571
ClinVar: 571
TCGA: ENSG00000156273
COSMIC: BACH1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000156273	ENST00000286800	O14867
ENSG00000156273	ENST00000399921	O14867
ENSG00000156273	ENST00000422809	H7C4B6
ENSG00000156273	ENST00000435072	C9IYH8
ENSG00000156273	ENST00000447177	C9JMP6
ENSG00000156273	ENST00000451655	C9IYR0
ENSG00000156273	ENST00000468059	M0QZP0
ENSG00000156273	ENST00000546469	F8VZL7
ENSG00000156273	ENST00000547141	F8VZL7
ENSG00000156273	ENST00000548219	F8VZL7
ENSG00000156273	ENST00000548467	F8VZL7
ENSG00000156273	ENST00000550131	F8VZL7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA164925725	Toxic liver disease	Disease	ClinicalAnnotation	associated	PD	22341855, 29036176
PA166119041	drug-induced liver injury	Disease	ClinicalAnnotation	associated	PD	22341855, 29036176
PA450112	isoniazid	Chemical	ClinicalAnnotation	associated	PD	22341855, 29036176

References

Pubmed ID	Year	Title	Citations
17881434	2007	Kaposi's sarcoma-associated herpesvirus encodes an ortholog of miR-155.	230
20127796	2010	MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins.	70
17065227	2006	Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin.	61
21555518	2011	The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.	60
21555518	2011	The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.	60
12511571	2003	Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells.	58
14660636	2004	Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells.	47
22698995	2012	The let-7 microRNA enhances heme oxygenase-1 by suppressing Bach1 and attenuates oxidant injury in human hepatocytes.	43
24395801	2014	Network of mutually repressive metastasis regulators can promote cell heterogeneity and metastatic transitions.	43
24035498	2013	Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover.	42

Citation

Dessen P

BACH1 (BTB domain and CNC homolog 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-01-01

Online version: http://atlasgeneticsoncology.org/gene/49965/bach1-(btb-domain-and-cnc-homolog-1)