Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 571
MIM: 602751
HGNC: 935
Ensembl: ENSG00000156273
Variants:
dbSNP: 571
ClinVar: 571
TCGA: ENSG00000156273
COSMIC: BACH1
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164925725 | Toxic liver disease | Disease | ClinicalAnnotation | associated | PD | 22341855, 29036176 | |
| PA166119041 | drug-induced liver injury | Disease | ClinicalAnnotation | associated | PD | 22341855, 29036176 | |
| PA450112 | isoniazid | Chemical | ClinicalAnnotation | associated | PD | 22341855, 29036176 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38673728 | 2024 | TANK Binding Kinase 1 Promotes BACH1 Degradation through Both Phosphorylation-Dependent and -Independent Mechanisms without Relying on Heme and FBXO22. | 0 |
| 38673728 | 2024 | TANK Binding Kinase 1 Promotes BACH1 Degradation through Both Phosphorylation-Dependent and -Independent Mechanisms without Relying on Heme and FBXO22. | 0 |
| 36178067 | 2023 | BACH1 promotes clear cell renal cell carcinoma progression by upregulating oxidative stress-related tumorigenicity. | 7 |
| 36453019 | 2023 | Ryanodine receptor 2 promotes colorectal cancer metastasis by the ROS/BACH1 axis. | 3 |
| 36670112 | 2023 | BACH1-induced ferroptosis drives lymphatic metastasis by repressing the biosynthesis of monounsaturated fatty acids. | 0 |
| 36774506 | 2023 | FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia. | 4 |
| 36864760 | 2023 | BACH1 deficiency prevents neointima formation and maintains the differentiated phenotype of vascular smooth muscle cells by regulating chromatin accessibility. | 5 |
| 37010133 | 2023 | Evaluation of Bach1 mRNA expression in patients with chronic kidney disease: A preliminary study. | 0 |
| 37094356 | 2023 | Ferroptosis model system by the re-expression of BACH1. | 6 |
| 37104068 | 2023 | Thioredoxin facilitates hepatocellular carcinoma stemness and metastasis by increasing BACH1 stability to activate the AKT/mTOR pathway. | 1 |
| 37311571 | 2023 | BACH1 promotes lung adenocarcinoma cell metastasis through transcriptional activation of ITGA2. | 0 |
| 37461019 | 2023 | Chemotherapy-induced exosomal circBACH1 promotes breast cancer resistance and stemness via miR-217/G3BP2 signaling pathway. | 5 |
| 37602966 | 2023 | Knockdown of Bach1 protects periodontal bone regeneration from inflammatory damage. | 2 |
| 37651203 | 2023 | Antioxidants stimulate BACH1-dependent tumor angiogenesis. | 2 |
| 37995178 | 2023 | BACH1 regulates the differentiation of vascular smooth muscle cells from human embryonic stem cells via CARM1-mediated methylation of H3R17. | 0 |
Citation
Dessen P
BACH1 (BTB domain and CNC homolog 1)
Atlas Genet Cytogenet Oncol Haematol. 2008-01-01
Online version: http://atlasgeneticsoncology.org/gene/49965/bach1-(btb-domain-and-cnc-homolog-1)
