PRMT2 (protein arginine methyltransferase 2)

2008-01-01  

Identity

HGNC
PRMT2
LOCATION
21q22.3
LOCUSID
3275
ALIAS
HRMT1L1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3275
MIM: 601961
HGNC: 5186
Ensembl: ENSG00000160310

Variants:

dbSNP: 3275
ClinVar: 3275
TCGA: ENSG00000160310
COSMIC: PRMT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160310ENST00000291705P55345
ENSG00000160310ENST00000334494P55345
ENSG00000160310ENST00000355680P55345
ENSG00000160310ENST00000355680A0A0S2Z3N3
ENSG00000160310ENST00000397628A8MXR3
ENSG00000160310ENST00000397637P55345
ENSG00000160310ENST00000397637A0A0S2Z3N3
ENSG00000160310ENST00000397638P55345
ENSG00000160310ENST00000397638A0A0S2Z3N3
ENSG00000160310ENST00000440086P55345
ENSG00000160310ENST00000451211P55345
ENSG00000160310ENST00000455177H7C2H9
ENSG00000160310ENST00000458387P55345
ENSG00000160310ENST00000621201A0A087WYX1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381554642024Advances in Research on Protein Arginine Methyltransferase 2: Functions and Diseases.1
388922172024Human C15orf39 Inhibits Inflammatory Response via PRMT2 in Human Microglial HMC3 Cell Line.0
389023492024Protein arginine methyltransferase 2 controls inflammatory signaling in acute myeloid leukemia.0
381554642024Advances in Research on Protein Arginine Methyltransferase 2: Functions and Diseases.1
388922172024Human C15orf39 Inhibits Inflammatory Response via PRMT2 in Human Microglial HMC3 Cell Line.0
389023492024Protein arginine methyltransferase 2 controls inflammatory signaling in acute myeloid leukemia.0
371733062023PRMT2 promotes RCC tumorigenesis and metastasis via enhancing WNT5A transcriptional expression.7
378632632023Protein arginine N-methyltransferase 2 plays a noncatalytic role in the histone methylation activity of PRMT1.2
379498792023PRMT2 promotes HIV-1 latency by preventing nucleolar exit and phase separation of Tat into the Super Elongation Complex.0
371733062023PRMT2 promotes RCC tumorigenesis and metastasis via enhancing WNT5A transcriptional expression.7
378632632023Protein arginine N-methyltransferase 2 plays a noncatalytic role in the histone methylation activity of PRMT1.2
379498792023PRMT2 promotes HIV-1 latency by preventing nucleolar exit and phase separation of Tat into the Super Elongation Complex.0
358359072022Loss of PRMT2 in myeloid cells in normoglycemic mice phenocopies impaired regression of atherosclerosis in diabetic mice.3
358359072022Loss of PRMT2 in myeloid cells in normoglycemic mice phenocopies impaired regression of atherosclerosis in diabetic mice.3
325746052020PRMT2 accelerates tumorigenesis of hepatocellular carcinoma by activating Bcl2 via histone H3R8 methylation.23

Citation

Dessen P

PRMT2 (protein arginine methyltransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-01-01

Online version: http://atlasgeneticsoncology.org/gene/49971/prmt2-(protein-arginine-methyltransferase-2)