RICTOR (RPTOR independent companion of MTOR complex 2)

2008-01-01  

Identity

HGNC
LOCATION
5p13.1
LOCUSID
ALIAS
AVO3,PIA,hAVO3
FUSION GENES

Other Information

Locus ID:

NCBI: 253260
MIM: 609022
HGNC: 28611
Ensembl: ENSG00000164327

Variants:

dbSNP: 253260
ClinVar: 253260
TCGA: ENSG00000164327
COSMIC: RICTOR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164327ENST00000296782Q6R327
ENSG00000164327ENST00000357387Q6R327
ENSG00000164327ENST00000511516Q6R327
ENSG00000164327ENST00000514735D6R9S6

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
mTOR signaling pathwayKEGGhsa04150
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
PI3K/AKT Signaling in CancerREACTOMER-HSA-2219528
Constitutive Signaling by AKT1 E17K in CancerREACTOMER-HSA-5674400
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Costimulation by the CD28 familyREACTOMER-HSA-388841
CD28 co-stimulationREACTOMER-HSA-389356
CD28 dependent PI3K/Akt signalingREACTOMER-HSA-389357
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)REACTOMER-HSA-1168372
PIP3 activates AKT signalingREACTOMER-HSA-1257604
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
Role of LAT2/NTAL/LAB on calcium mobilizationREACTOMER-HSA-2730905
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
GAB1 signalosomeREACTOMER-HSA-180292
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
PI3K/AKT activationREACTOMER-HSA-198203
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
VEGFR2 mediated vascular permeabilityREACTOMER-HSA-5218920
Signaling by SCF-KITREACTOMER-HSA-1433557
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Expression and DegradationREACTOMER-HSA-6806003
Regulation of TP53 DegradationREACTOMER-HSA-6804757

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
157184702005Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.2480
169626532006SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.591
170433092006Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity.213
194028212009Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR).203
174617792007Identification of Protor as a novel Rictor-binding component of mTOR complex-2.172
199959152010mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.170
204127742010The CST3 BB genotype and low cystatin C cerebrospinal fluid levels are associated with dementia in Lewy body disease.121
242702652014Mammalian target of rapamycin complex 2 (mTORC2) coordinates pulmonary artery smooth muscle cell metabolism, proliferation, and survival in pulmonary arterial hypertension.66
213436172011ER stress inhibits mTORC2 and Akt signaling through GSK-3β-mediated phosphorylation of rictor.57
169598812006Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes.51

Citation

Dessen P

RICTOR (RPTOR independent companion of MTOR complex 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-01-01

Online version: http://atlasgeneticsoncology.org/gene/49986/rictor-(rptor-independent-companion-of-mtor-complex-2)