ARC (activity regulated cytoskeleton associated protein)

2008-01-01  

Identity

HGNC
ARC
LOCATION
8q24.3
LOCUSID
23237
ALIAS
Arg3.1,hArc

Other Information

Locus ID:

NCBI: 23237
MIM: 612461
HGNC: 648
Ensembl: ENSG00000198576

Variants:

dbSNP: 23237
ClinVar: 23237
TCGA: ENSG00000198576
COSMIC: ARC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198576ENST00000356613Q7LC44

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031

References

Pubmed IDYearTitleCitations
220365692011Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation.76
171202802007Dynamics of bidirectional transport of Arc mRNA in neuronal dendrites.47
249457732014Triad3A regulates synaptic strength by ubiquitination of Arc.35
223028112012Contrast-enhanced magnetic resonance microangiography reveals remodeling of the cerebral microvasculature in transgenic ArcAβ mice.29
225845812012Balancing Arc synthesis, mRNA decay, and proteasomal degradation: maximal protein expression triggered by rapid eye movement sleep-like bursts of muscarinic cholinergic receptor stimulation.29
257480422015Arc is a flexible modular protein capable of reversible self-oligomerization.19
264744112015Association of SNPs in EGR3 and ARC with Schizophrenia Supports a Biological Pathway for Schizophrenia Risk.18
260388302015Altered Markers of Cortical γ-Aminobutyric Acid Neuronal Activity in Schizophrenia: Role of the NARP Gene.15
279957692017TRIAD3/RNF216 mutations associated with Gordon Holmes syndrome lead to synaptic and cognitive impairments via Arc misregulation.13
305697992019Long noncoding RNA PCAT6 inhibits colon cancer cell apoptosis by regulating anti-apoptotic protein ARC expression via EZH2.9

Citation

Dessen P

ARC (activity regulated cytoskeleton associated protein)

Atlas Genet Cytogenet Oncol Haematol. 2008-01-01

Online version: http://atlasgeneticsoncology.org/gene/49990/arc-(activity-regulated-cytoskeleton-associated-protein)