CD96 (CD96 molecule)

2008-01-01  

Identity

HGNC
LOCATION
3q13.13
LOCUSID
ALIAS
TACTILE
FUSION GENES

Other Information

Locus ID:

NCBI: 10225
MIM: 606037
HGNC: 16892
Ensembl: ENSG00000153283

Variants:

dbSNP: 10225
ClinVar: 10225
TCGA: ENSG00000153283
COSMIC: CD96

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153283ENST00000283285P40200
ENSG00000153283ENST00000352690P40200
ENSG00000153283ENST00000438817Q8WUE2
ENSG00000153283ENST00000460744U3KPT0
ENSG00000153283ENST00000465428H7C4F0
ENSG00000153283ENST00000488054F8WDV3
ENSG00000153283ENST00000494798E9PEJ1

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
150340102004Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155).112
175769272007CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia.96
276202762016Molecular Pathways: Targeting CD96 and TIGIT for Cancer Immunotherapy.52
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
304113782019Human CD96 Correlates to Natural Killer Cell Exhaustion and Predicts the Prognosis of Human Hepatocellular Carcinoma.27
190567332009CD96 interaction with CD155 via its first Ig-like domain is modulated by alternative splicing or mutations in distal Ig-like domains.21
178470092007Mutations in CD96, a member of the immunoglobulin superfamily, cause a form of the C (Opitz trigonocephaly) syndrome.14
247513332014Expression of CD90, CD96, CD117, and CD123 on different hematopoietic cell populations from pediatric patients with acute myeloid leukemia.10
295310702018CD96 expression determines the inflammatory potential of IL-9-producing Th9 cells.8
305285962019Structural Basis for CD96 Immune Receptor Recognition of Nectin-like Protein-5, CD155.8

Citation

Dessen P

CD96 (CD96 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2008-01-01

Online version: http://atlasgeneticsoncology.org/gene/49991/cd96-(cd96-molecule)