LSR (lipolysis stimulated lipoprotein receptor)

2007-02-01  

Identity

HGNC
LSR
LOCATION
19q13.12
LOCUSID
51599
ALIAS
ILDR3,LISCH7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51599
MIM: 616582
HGNC: 29572
Ensembl: ENSG00000105699

Variants:

dbSNP: 51599
ClinVar: 51599
TCGA: ENSG00000105699
COSMIC: LSR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105699ENST00000347609Q86X29
ENSG00000105699ENST00000354900Q86X29
ENSG00000105699ENST00000360798Q86X29
ENSG00000105699ENST00000361790Q86X29
ENSG00000105699ENST00000427250Q86X29
ENSG00000105699ENST00000599658M0QZL9
ENSG00000105699ENST00000601623M0R1W9
ENSG00000105699ENST00000602003M0R0W1
ENSG00000105699ENST00000602122Q86X29
ENSG00000105699ENST00000605618S4R3V8
ENSG00000105699ENST00000621372Q86X29

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
LDL-mediated lipid transportREACTOMER-HSA-171052
VLDL interactionsREACTOMER-HSA-8855121

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
369618822023Downregulation of angulin-1/LSR induces malignancy via upregulation of EGF-dependent claudin-2 and TGF-β-dependent cell metabolism in human lung adenocarcinoma A549 cells.2
369618822023Downregulation of angulin-1/LSR induces malignancy via upregulation of EGF-dependent claudin-2 and TGF-β-dependent cell metabolism in human lung adenocarcinoma A549 cells.2
333884152021LSR promotes epithelial ovarian cancer cell survival under energy stress through the LKB1-AMPK pathway.3
337631522021LSR Promotes Cell Proliferation and Invasion in Lung Cancer.4
344035062021Translocation of LSR from tricellular corners causes macropinocytosis at cell-cell interface as a trigger for breaking out of contact inhibition.1
333884152021LSR promotes epithelial ovarian cancer cell survival under energy stress through the LKB1-AMPK pathway.3
337631522021LSR Promotes Cell Proliferation and Invasion in Lung Cancer.4
344035062021Translocation of LSR from tricellular corners causes macropinocytosis at cell-cell interface as a trigger for breaking out of contact inhibition.1
316502472020Tricellular tight junction protein LSR/angulin-1 contributes to the epithelial barrier and malignancy in human pancreatic cancer cell line.12
316620222020Localization of Tricellular Tight Junction Molecule LSR at Midbody and Centrosome During Cytokinesis in Human Epithelial Cells.6
320487502020Potentiation of cancerous progression by LISCH7 via direct stimulation of TGFB1 transcription in triple-negative breast cancer.1
322664592020ASPP2 suppression promotes malignancy via LSR and YAP in human endometrial cancer.10
324238022020HMGB1-downregulated angulin-1/LSR induces epithelial barrier disruption via claudin-2 and cellular metabolism via AMPK in airway epithelial Calu-3 cells.12
331056842020Leptin Downregulates Angulin-1 in Active Crohn's Disease via STAT3.6
316502472020Tricellular tight junction protein LSR/angulin-1 contributes to the epithelial barrier and malignancy in human pancreatic cancer cell line.12

Citation

Dessen P

LSR (lipolysis stimulated lipoprotein receptor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/50010/lsr-(lipolysis-stimulated-lipoprotein-receptor)