TPPP (tubulin polymerization promoting protein)

2007-02-01  

Identity

HGNC
TPPP
LOCATION
5p15.33
LOCUSID
11076
ALIAS
TPPP/p25,TPPP1,p24,p25,p25alpha
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11076
MIM: 608773
HGNC: 24164
Ensembl: ENSG00000171368

Variants:

dbSNP: 11076
ClinVar: 11076
TCGA: ENSG00000171368
COSMIC: TPPP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171368ENST00000360578O94811
ENSG00000171368ENST00000360578Q4L233

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383919512024Perspective Strategies for Interventions in Parkinsonism: Remedying the Neglected Role of TPPP.0
383919512024Perspective Strategies for Interventions in Parkinsonism: Remedying the Neglected Role of TPPP.0
350623492022HERV-W Envelope Triggers Abnormal Dopaminergic Neuron Process through DRD2/PP2A/AKT1/GSK3 for Schizophrenia Risk.12
350623492022HERV-W Envelope Triggers Abnormal Dopaminergic Neuron Process through DRD2/PP2A/AKT1/GSK3 for Schizophrenia Risk.12
348311322021Anti-Aggregative Effect of the Antioxidant DJ-1 on the TPPP/p25-Derived Pathological Associations of Alpha-Synuclein.1
348311322021Anti-Aggregative Effect of the Antioxidant DJ-1 on the TPPP/p25-Derived Pathological Associations of Alpha-Synuclein.1
315051702019Interactions between two regulatory proteins of microtubule dynamics, HDAC6, TPPP/p25, and the hub protein, DYNLL/LC8.2
315228872019The Golgi Outpost Protein TPPP Nucleates Microtubules and Is Critical for Myelination.51
316311742019YY1 targets tubulin polymerisation-promoting protein to inhibit migration, invasion and angiogenesis in pancreatic cancer via p38/MAPK and PI3K/AKT pathways.20
315051702019Interactions between two regulatory proteins of microtubule dynamics, HDAC6, TPPP/p25, and the hub protein, DYNLL/LC8.2
315228872019The Golgi Outpost Protein TPPP Nucleates Microtubules and Is Critical for Myelination.51
316311742019YY1 targets tubulin polymerisation-promoting protein to inhibit migration, invasion and angiogenesis in pancreatic cancer via p38/MAPK and PI3K/AKT pathways.20
276718642017Challenging drug target for Parkinson's disease: Pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins.13
280749112017Further evidence for microtubule-independent dimerization of TPPP/p25.9
282717392017Role of the microtubule-associated TPPP/p25 in Parkinson's and related diseases and its therapeutic potential.11

Citation

Dessen P

TPPP (tubulin polymerization promoting protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/50011/tppp-(tubulin-polymerization-promoting-protein)