ATAD2 (ATPase family AAA domain containing 2)

2007-02-01  

Identity

HGNC
LOCATION
8q24.13
LOCUSID
ALIAS
ANCCA,CT137,PRO2000
FUSION GENES

Other Information

Locus ID:

NCBI: 29028
MIM: 611941
HGNC: 30123
Ensembl: ENSG00000156802

Variants:

dbSNP: 29028
ClinVar: 29028
TCGA: ENSG00000156802
COSMIC: ATAD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156802ENST00000287394Q6PL18
ENSG00000156802ENST00000287394A0A024R9G7
ENSG00000156802ENST00000517666E5RIP2
ENSG00000156802ENST00000519124E5RHW7
ENSG00000156802ENST00000521903A0A0B4J211

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsREACTOMER-HSA-8864260
TFAP2 (AP-2) family regulates transcription of growth factors and their receptorsREACTOMER-HSA-8866910

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
375954462023MicroRNA-139-5p suppresses non-small cell lung cancer progression by targeting ATAD2.1
377706452023Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication.0
375954462023MicroRNA-139-5p suppresses non-small cell lung cancer progression by targeting ATAD2.1
377706452023Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication.0
334385262022Oncogenic potential of ATAD2 in stomach cancer and insights into the protein-protein interactions at its AAA + ATPase domain and bromodomain.3
350858912022ATAD2 drives colorectal cancer progression by regulating TRIM25 expression via a positive feedback loop with E2F transcriptional factors.4
356726942022Effect of chronic intermittent hypoxia-induced HIF-1α/ATAD2 expression on lung cancer stemness.13
360089342022Tumor-Promoting ATAD2 and Its Preclinical Challenges.4
364790432022ATAD2 Upregulation Promotes Tumor Growth and Angiogenesis in Endometrial Cancer and Is Associated with Its Immune Infiltration.3
334385262022Oncogenic potential of ATAD2 in stomach cancer and insights into the protein-protein interactions at its AAA + ATPase domain and bromodomain.3
350858912022ATAD2 drives colorectal cancer progression by regulating TRIM25 expression via a positive feedback loop with E2F transcriptional factors.4
356726942022Effect of chronic intermittent hypoxia-induced HIF-1α/ATAD2 expression on lung cancer stemness.13
360089342022Tumor-Promoting ATAD2 and Its Preclinical Challenges.4
364790432022ATAD2 Upregulation Promotes Tumor Growth and Angiogenesis in Endometrial Cancer and Is Associated with Its Immune Infiltration.3
337575722021ATAD2 interacts with C/EBPβ to promote esophageal squamous cell carcinoma metastasis via TGF-β1/Smad3 signaling.13

Citation

Dessen P

ATAD2 (ATPase family AAA domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/50030/atad2-(atpase-family-aaa-domain-containing-2)