SYNM (synemin)

2007-02-01 Affiliation

Identity

HGNC

SYNM

LOCATION

15q26.3

LOCUSID

23336

ALIAS

DMN,SYN

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 23336
MIM: 606087
HGNC: 24466
Ensembl: ENSG00000182253

Variants:

dbSNP: 23336
ClinVar: 23336
TCGA: ENSG00000182253
COSMIC: SYNM

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000182253	ENST00000328642	C9JIE4
ENSG00000182253	ENST00000336292	O15061
ENSG00000182253	ENST00000560674	H0YL34
ENSG00000182253	ENST00000594047	A0A075B7B1

Expression (GTEx)

500

1000

1500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
35361267	2022	A risk model of gene signatures for predicting platinum response and survival in ovarian cancer.	9
35769011	2022	Synemin promotes pulmonary artery smooth muscle cell phenotypic switch in shunt-induced pulmonary arterial hypertension.	4
35361267	2022	A risk model of gene signatures for predicting platinum response and survival in ovarian cancer.	9
35769011	2022	Synemin promotes pulmonary artery smooth muscle cell phenotypic switch in shunt-induced pulmonary arterial hypertension.	4
33019757	2020	c-Abl Tyrosine Kinase Is Regulated Downstream of the Cytoskeletal Protein Synemin in Head and Neck Squamous Cell Carcinoma Radioresistance and DNA Repair.	5
33019757	2020	c-Abl Tyrosine Kinase Is Regulated Downstream of the Cytoskeletal Protein Synemin in Head and Neck Squamous Cell Carcinoma Radioresistance and DNA Repair.	5
30276801	2019	A novel heterozygous variant p.(Trp538Arg) of SYNM is identified by whole-exome sequencing in a Chinese family with dilated cardiomyopathy.	5
31461342	2019	Identification of the intermediate filament protein synemin/SYNM as a target of myocardin family coactivators.	11
30276801	2019	A novel heterozygous variant p.(Trp538Arg) of SYNM is identified by whole-exome sequencing in a Chinese family with dilated cardiomyopathy.	5
31461342	2019	Identification of the intermediate filament protein synemin/SYNM as a target of myocardin family coactivators.	11
27470516	2016	Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM.	40
27470516	2016	Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM.	40
23594359	2014	Synemin is expressed in reactive astrocytes and Rosenthal fibers in Alexander disease.	14
25447537	2014	α-Synemin localizes to the M-band of the sarcomere through interaction with the M10 region of titin.	6
23594359	2014	Synemin is expressed in reactive astrocytes and Rosenthal fibers in Alexander disease.	14

Citation

Dessen P

SYNM (synemin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/50031/synm-(synemin)