RPLP0 (ribosomal protein lateral stalk subunit P0)

2008-03-01 Affiliation

Identity

HGNC

RPLP0

LOCATION

12q24.23

LOCUSID

6175

ALIAS

L10E,LP0,P0,PRLP0,RPP0

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6175
MIM: 180510
HGNC: 10371
Ensembl: ENSG00000089157

Variants:

dbSNP: 6175
ClinVar: 6175
TCGA: ENSG00000089157
COSMIC: RPLP0

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000089157	ENST00000228306	P05388
ENSG00000089157	ENST00000228306	A0A024RBS2
ENSG00000089157	ENST00000313104	P05388
ENSG00000089157	ENST00000392514	P05388
ENSG00000089157	ENST00000392514	A0A024RBS2
ENSG00000089157	ENST00000546989	F8VWS0
ENSG00000089157	ENST00000546990	F8VZS0
ENSG00000089157	ENST00000547173	G3V210
ENSG00000089157	ENST00000547191	F8VPE8
ENSG00000089157	ENST00000547211	F8VW21
ENSG00000089157	ENST00000547475	F8VQY6
ENSG00000089157	ENST00000549098	F8VYN4
ENSG00000089157	ENST00000550423	F8VWV4
ENSG00000089157	ENST00000550856	F8VU65
ENSG00000089157	ENST00000551150	P05388
ENSG00000089157	ENST00000551150	A0A024RBS2
ENSG00000089157	ENST00000551258	F8VRK7
ENSG00000089157	ENST00000551914	F8VS58
ENSG00000089157	ENST00000552292	F8W1K8

Expression (GTEx)

500

1000

1500

2000

2500

3000

3500

4000

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Ribosome	KEGG	ko03010
Ribosome	KEGG	hsa03010
Ribosome, eukaryotes	KEGG	hsa_M00177
Ribosome, eukaryotes	KEGG	M00177
Metabolism of proteins	REACTOME	R-HSA-392499
Translation	REACTOME	R-HSA-72766
Eukaryotic Translation Initiation	REACTOME	R-HSA-72613
Cap-dependent Translation Initiation	REACTOME	R-HSA-72737
Formation of a pool of free 40S subunits	REACTOME	R-HSA-72689
GTP hydrolysis and joining of the 60S ribosomal subunit	REACTOME	R-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expression	REACTOME	R-HSA-156827
SRP-dependent cotranslational protein targeting to membrane	REACTOME	R-HSA-1799339
Eukaryotic Translation Elongation	REACTOME	R-HSA-156842
Peptide chain elongation	REACTOME	R-HSA-156902
Eukaryotic Translation Termination	REACTOME	R-HSA-72764
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
Influenza Infection	REACTOME	R-HSA-168254
Influenza Life Cycle	REACTOME	R-HSA-168255
Influenza Viral RNA Transcription and Replication	REACTOME	R-HSA-168273
Viral mRNA Translation	REACTOME	R-HSA-192823
Gene Expression	REACTOME	R-HSA-74160
Nonsense-Mediated Decay (NMD)	REACTOME	R-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	REACTOME	R-HSA-975957
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	REACTOME	R-HSA-975956
Metabolism	REACTOME	R-HSA-1430728
Metabolism of amino acids and derivatives	REACTOME	R-HSA-71291
Selenoamino acid metabolism	REACTOME	R-HSA-2408522
Selenocysteine synthesis	REACTOME	R-HSA-2408557
rRNA processing	REACTOME	R-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosol	REACTOME	R-HSA-6791226
rRNA processing in the nucleus and cytosol	REACTOME	R-HSA-8868773

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
35974014	2022	DNA damage-induced paraspeckle formation enhances DNA repair and tumor radioresistance by recruiting ribosomal protein P0.	9
35974014	2022	DNA damage-induced paraspeckle formation enhances DNA repair and tumor radioresistance by recruiting ribosomal protein P0.	9
32668052	2020	Phosphorylation of the N-terminal domain of ribosomal P-stalk protein uL10 governs its association with the ribosome.	2
32668052	2020	Phosphorylation of the N-terminal domain of ribosomal P-stalk protein uL10 governs its association with the ribosome.	2
28986221	2018	The uL10 protein, a component of the ribosomal P-stalk, is released from the ribosome in nucleolar stress.	11
28986221	2018	The uL10 protein, a component of the ribosomal P-stalk, is released from the ribosome in nucleolar stress.	11
25307291	2015	Association of anti-acidic ribosomal protein P0 and anti-galectin 3 antibodies with the development of skin lesions in systemic lupus erythematosus.	11
25433997	2015	Dysregulation of apoptotic signaling pathways by interaction of RPLP0 and cathepsin X/Z in gastric cancer.	21
25889931	2015	Natural humoral immune response to ribosomal P0 protein in colorectal cancer patients.	11
26176264	2015	Disruption of the ribosomal P complex leads to stress-induced autophagy.	39
25307291	2015	Association of anti-acidic ribosomal protein P0 and anti-galectin 3 antibodies with the development of skin lesions in systemic lupus erythematosus.	11
25433997	2015	Dysregulation of apoptotic signaling pathways by interaction of RPLP0 and cathepsin X/Z in gastric cancer.	21
25889931	2015	Natural humoral immune response to ribosomal P0 protein in colorectal cancer patients.	11
26176264	2015	Disruption of the ribosomal P complex leads to stress-induced autophagy.	39
23400861	2013	Significance of antibodies against the native ribosomal P protein complex and recombinant P0, P1, and P2 proteins in the diagnosis of Chinese patients with systemic lupus erythematosus.	3

Citation

Dessen P

RPLP0 (ribosomal protein lateral stalk subunit P0)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/gene/50046/rplp0-(ribosomal-protein-lateral-stalk-subunit-p0)