NOX5 (NADPH oxidase 5)

2008-03-01  

Identity

HGNC
NOX5
LOCATION
15q23
LOCUSID
79400
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79400
MIM: 606572
HGNC: 14874
Ensembl: ENSG00000255346

Variants:

dbSNP: 79400
ClinVar: 79400
TCGA: ENSG00000255346
COSMIC: NOX5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000255346ENST00000260364Q96PH1
ENSG00000255346ENST00000388866Q96PH1
ENSG00000255346ENST00000448182Q96PH1
ENSG00000255346ENST00000455873Q96PH1
ENSG00000255346ENST00000525143A0A0B4J289
ENSG00000255346ENST00000530406Q96PH1

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
Detoxification of Reactive Oxygen SpeciesREACTOMER-HSA-3299685

References

Pubmed IDYearTitleCitations
387347612024Structural basis of human NOX5 activation.0
387347612024Structural basis of human NOX5 activation.0
363327492023NOX2 and NOX5 are increased in cardiac microvascular endothelium of deceased COVID-19 patients.6
366538382023Ca(2+) -binding-region-dependent cell surface localization of NADPH oxidase Nox5.0
369054562023Structure, regulation, and physiological functions of NADPH oxidase 5 (NOX5).8
363327492023NOX2 and NOX5 are increased in cardiac microvascular endothelium of deceased COVID-19 patients.6
366538382023Ca(2+) -binding-region-dependent cell surface localization of NADPH oxidase Nox5.0
369054562023Structure, regulation, and physiological functions of NADPH oxidase 5 (NOX5).8
342731662022Nicotine promotes vascular calcification via intracellular Ca2+-mediated, Nox5-induced oxidative stress, and extracellular vesicle release in vascular smooth muscle cells.18
352759882022Independent of Renox, NOX5 Promotes Renal Inflammation and Fibrosis in Diabetes by Activating ROS-Sensitive Pathways.17
356795082022Impact of calcium and reactive oxygen species on human sperm function: Role of NOX5.2
342731662022Nicotine promotes vascular calcification via intracellular Ca2+-mediated, Nox5-induced oxidative stress, and extracellular vesicle release in vascular smooth muscle cells.18
352759882022Independent of Renox, NOX5 Promotes Renal Inflammation and Fibrosis in Diabetes by Activating ROS-Sensitive Pathways.17
356795082022Impact of calcium and reactive oxygen species on human sperm function: Role of NOX5.2
337849902021NOX5 is expressed aberrantly but not a critical pathogenetic gene in Hirschsprung disease.2

Citation

Dessen P

NOX5 (NADPH oxidase 5)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/gene/50047/nox5-(nadph-oxidase-5)