TRPC3 (transient receptor potential cation channel subfamily C member 3)

2008-03-01  

Identity

HGNC
TRPC3
LOCATION
4q27
LOCUSID
7222
ALIAS
SCA41,TRP3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7222
MIM: 602345
HGNC: 12335
Ensembl: ENSG00000138741

Variants:

dbSNP: 7222
ClinVar: 7222
TCGA: ENSG00000138741
COSMIC: TRPC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138741ENST00000264811Q13507
ENSG00000138741ENST00000379645Q13507
ENSG00000138741ENST00000502968D6R902
ENSG00000138741ENST00000506449D6RC49
ENSG00000138741ENST00000513531J3QTB0

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Platelet calcium homeostasisREACTOMER-HSA-418360
Elevation of cytosolic Ca2+ levelsREACTOMER-HSA-139853
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Effects of PIP2 hydrolysisREACTOMER-HSA-114508
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351
TRP channelsREACTOMER-HSA-3295583
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752
Role of second messengers in netrin-1 signalingREACTOMER-HSA-418890

References

Pubmed IDYearTitleCitations
377551442024MiRNA-26a-5p inhibits preterm labor initiation by targeting and regulating TRPC3 ion channel protein expression.0
379772702024New insights in the renal distribution profile of TRPC3 - Of mice and men.4
386739772024TRPC3 Is Downregulated in Primary Hyperparathyroidism.0
387717352024Protective Role of TRPC3 Gene Polymorphism (rs10518289) in Obstructive Sleep Apnea Hypopnea Syndrome Among Hypertensive Patients.0
377551442024MiRNA-26a-5p inhibits preterm labor initiation by targeting and regulating TRPC3 ion channel protein expression.0
379772702024New insights in the renal distribution profile of TRPC3 - Of mice and men.4
386739772024TRPC3 Is Downregulated in Primary Hyperparathyroidism.0
387717352024Protective Role of TRPC3 Gene Polymorphism (rs10518289) in Obstructive Sleep Apnea Hypopnea Syndrome Among Hypertensive Patients.0
366428382023TRPC3 Regulates Islet Beta-Cell Insulin Secretion.2
366745432023Rs11726196 Single-Nucleotide Polymorphism of the Transient Receptor Potential Canonical 3 (TRPC3) Gene Is Associated with Chronic Pain.1
370624362023Reduction of TRPC1/TRPC3 mediated Ca(2+)-signaling protects oxidative stress-induced COPD.1
377594382023Modulation and Regulation of Canonical Transient Receptor Potential 3 (TRPC3) Channels.3
366428382023TRPC3 Regulates Islet Beta-Cell Insulin Secretion.2
366745432023Rs11726196 Single-Nucleotide Polymorphism of the Transient Receptor Potential Canonical 3 (TRPC3) Gene Is Associated with Chronic Pain.1
370624362023Reduction of TRPC1/TRPC3 mediated Ca(2+)-signaling protects oxidative stress-induced COPD.1

Citation

Dessen P

TRPC3 (transient receptor potential cation channel subfamily C member 3)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/gene/50070/trpc3-(transient-receptor-potential-cation-channel-subfamily-c-member-3)