RRN3 (RRN3 homolog, RNA polymerase I transcription factor)

2008-04-01  

Identity

HGNC
LOCATION
16p13.11
LOCUSID
ALIAS
A-270G1.2,TIFIA
FUSION GENES

Other Information

Locus ID:

NCBI: 54700
MIM: 605121
HGNC: 30346
Ensembl: ENSG00000085721

Variants:

dbSNP: 54700
ClinVar: 54700
TCGA: ENSG00000085721
COSMIC: RRN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000085721ENST00000198767Q9NYV6
ENSG00000085721ENST00000327307Q9NYV6
ENSG00000085721ENST00000429751F5H148
ENSG00000085721ENST00000563559H3BMT1
ENSG00000085721ENST00000564131Q9NYV6

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase I TranscriptionREACTOMER-HSA-73864
RNA Polymerase I Promoter ClearanceREACTOMER-HSA-73854
RNA Polymerase I Transcription InitiationREACTOMER-HSA-73762
RNA Polymerase I Promoter EscapeREACTOMER-HSA-73772

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
371193702023High RRN3 expression is associated with malignant characteristics and poor prognosis in pancreatic cancer.1
371193702023High RRN3 expression is associated with malignant characteristics and poor prognosis in pancreatic cancer.1
307937662019Ebp1 p48 promotes oncogenic activities in human colon cancer cells through regulation of TIF-90-mediated ribosomal RNA synthesis.7
307937662019Ebp1 p48 promotes oncogenic activities in human colon cancer cells through regulation of TIF-90-mediated ribosomal RNA synthesis.7
298737802018Identification of a novel TIF-IA-NF-κB nucleolar stress response pathway.13
298737802018Identification of a novel TIF-IA-NF-κB nucleolar stress response pathway.13
233931352013DNA binding by the ribosomal DNA transcription factor rrn3 is essential for ribosomal DNA transcription.17
242979012013Akt activation enhances ribosomal RNA synthesis through casein kinase II and TIF-IA.37
233931352013DNA binding by the ribosomal DNA transcription factor rrn3 is essential for ribosomal DNA transcription.17
242979012013Akt activation enhances ribosomal RNA synthesis through casein kinase II and TIF-IA.37
219407642011Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth.48
219407642011Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth.48
185594192008Phosphorylation by casein kinase 2 facilitates rRNA gene transcription by promoting dissociation of TIF-IA from elongating RNA polymerase I.39
185594192008Phosphorylation by casein kinase 2 facilitates rRNA gene transcription by promoting dissociation of TIF-IA from elongating RNA polymerase I.39
180476492007Biased exonization of transposed elements in duplicated genes: A lesson from the TIF-IA gene.15

Citation

Dessen P

RRN3 (RRN3 homolog, RNA polymerase I transcription factor)

Atlas Genet Cytogenet Oncol Haematol. 2008-04-01

Online version: http://atlasgeneticsoncology.org/gene/50094/rrn3-(rrn3-homolog-rna-polymerase-i-transcription-factor)