PPFIA1 (PTPRF interacting protein alpha 1)

2008-04-01 Affiliation

Identity

HGNC

PPFIA1

LOCATION

11q13.3

LOCUSID

8500

ALIAS

LIP.1,LIP1,LIPRIN

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8500
MIM: 611054
HGNC: 9245
Ensembl: ENSG00000131626

Variants:

dbSNP: 8500
ClinVar: 8500
TCGA: ENSG00000131626
COSMIC: PPFIA1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000131626	ENST00000253925	Q13136
ENSG00000131626	ENST00000389547	Q13136
ENSG00000131626	ENST00000526262	H0YEF9
ENSG00000131626	ENST00000526369	H0YF15
ENSG00000131626	ENST00000528750	H0YDW2
ENSG00000131626	ENST00000528853	H0YDZ8
ENSG00000131626	ENST00000530390	H0YEK0
ENSG00000131626	ENST00000530746	E9PPF6
ENSG00000131626	ENST00000530798	H0YD72
ENSG00000131626	ENST00000532024	E9PID5
ENSG00000131626	ENST00000532504	E9PJZ7
ENSG00000131626	ENST00000533894	H0YD39
ENSG00000131626	ENST00000638133	A0A1B0GVT3
ENSG00000131626	ENST00000644155	A0A2R8Y7R9
ENSG00000131626	ENST00000648755	A0A3B3ITS2

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Release Cycle	REACTOME	R-HSA-112310
Norepinephrine Neurotransmitter Release Cycle	REACTOME	R-HSA-181430
Serotonin Neurotransmitter Release Cycle	REACTOME	R-HSA-181429
Glutamate Neurotransmitter Release Cycle	REACTOME	R-HSA-210500
Dopamine Neurotransmitter Release Cycle	REACTOME	R-HSA-212676
Acetylcholine Neurotransmitter Release Cycle	REACTOME	R-HSA-264642

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38264964	2024	Liprin-α1 contributes to oncogenic MAPK signaling by counteracting ERK activity.	0
38264964	2024	Liprin-α1 contributes to oncogenic MAPK signaling by counteracting ERK activity.	0
37158817	2023	High expression of PPFIA1 in human esophageal squamous cell carcinoma correlates with tumor metastasis and poor prognosis.	1
37158817	2023	High expression of PPFIA1 in human esophageal squamous cell carcinoma correlates with tumor metastasis and poor prognosis.	1
33215388	2021	Quantifying Polarized Extracellular Matrix Secretion in Cultured Endothelial Cells.	2
33761347	2021	Oligomerized liprin-α promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins.	15
33215388	2021	Quantifying Polarized Extracellular Matrix Secretion in Cultured Endothelial Cells.	2
33761347	2021	Oligomerized liprin-α promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins.	15
30805892	2019	Combined expression and prognostic significance of PPFIA1 and ALG3 in head and neck squamous cell carcinoma.	10
30805892	2019	Combined expression and prognostic significance of PPFIA1 and ALG3 in head and neck squamous cell carcinoma.	10
29348417	2018	Identification of a membrane-less compartment regulating invadosome function and motility.	13
30005669	2018	Liprin-α1 modulates cancer cell signaling by transmembrane protein CD82 in adhesive membrane domains linked to cytoskeleton.	12
29348417	2018	Identification of a membrane-less compartment regulating invadosome function and motility.	13
30005669	2018	Liprin-α1 modulates cancer cell signaling by transmembrane protein CD82 in adhesive membrane domains linked to cytoskeleton.	12
28720060	2017	PPFIA1 is upregulated in liver metastasis of breast cancer and is a potential poor prognostic indicator of metastatic relapse.	10

Citation

Dessen P

PPFIA1 (PTPRF interacting protein alpha 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-04-01

Online version: http://atlasgeneticsoncology.org/gene/50099/ppfia1-(ptprf-interacting-protein-alpha-1)