BRF1 (BRF1 RNA polymerase III transcription initiation factor subunit)

2008-05-01  

Identity

HGNC
LOCATION
14q32.33
LOCUSID
ALIAS
BRF,BRF-1,CFDS,GTF3B,HEL-S-76p,TAF3B2,TAF3C,TAFIII90,TF3B90,TFIIIB90,hBRF
FUSION GENES

Other Information

Locus ID:

NCBI: 2972
MIM: 604902
HGNC: 11551
Ensembl: ENSG00000185024

Variants:

dbSNP: 2972
ClinVar: 2972
TCGA: ENSG00000185024
COSMIC: BRF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185024ENST00000327359Q92994
ENSG00000185024ENST00000379932F6VUY7
ENSG00000185024ENST00000379937Q92994
ENSG00000185024ENST00000392557Q92994
ENSG00000185024ENST00000392557A0A024R6P8
ENSG00000185024ENST00000440513Q92994
ENSG00000185024ENST00000446501Q92994
ENSG00000185024ENST00000546417H0YIV6
ENSG00000185024ENST00000547530Q92994
ENSG00000185024ENST00000548421Q92994
ENSG00000185024ENST00000548421V9HVY2
ENSG00000185024ENST00000549655F8VS45
ENSG00000185024ENST00000550208F8VWY1
ENSG00000185024ENST00000550375F8W123
ENSG00000185024ENST00000550692F8VXJ4
ENSG00000185024ENST00000551787Q3SYD7
ENSG00000185024ENST00000552127F8VWT8
ENSG00000185024ENST00000619151A3KN61

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase III TranscriptionREACTOMER-HSA-74158
RNA Polymerase III Abortive And Retractive InitiationREACTOMER-HSA-749476
RNA Polymerase III Transcription InitiationREACTOMER-HSA-76046
RNA Polymerase III Transcription Initiation From Type 1 PromoterREACTOMER-HSA-76061
RNA Polymerase III Transcription Initiation From Type 2 PromoterREACTOMER-HSA-76066

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
359258372023TFIIB-related factor 1 is a nucleolar protein that promotes RNA polymerase I-directed transcription and tumour cell growth.0
359258372023TFIIB-related factor 1 is a nucleolar protein that promotes RNA polymerase I-directed transcription and tumour cell growth.0
349356852022A novel BRF1 mutation in two middle-aged siblings with cerebellofaciodental syndrome.0
349356852022A novel BRF1 mutation in two middle-aged siblings with cerebellofaciodental syndrome.0
336459012021Cerebellofaciodental syndrome in an adult patient: Expanding the phenotypic and natural history characteristics.2
339253582021Comprehensive Analysis of Prognostic and Genetic Signatures for General Transcription Factor III (GTF3) in Clinical Colorectal Cancer Patients Using Bioinformatics Approaches.16
349289352021tRNA biogenesis and specific aminoacyl-tRNA synthetases regulate senescence stability under the control of mTOR.5
336459012021Cerebellofaciodental syndrome in an adult patient: Expanding the phenotypic and natural history characteristics.2
339253582021Comprehensive Analysis of Prognostic and Genetic Signatures for General Transcription Factor III (GTF3) in Clinical Colorectal Cancer Patients Using Bioinformatics Approaches.16
349289352021tRNA biogenesis and specific aminoacyl-tRNA synthetases regulate senescence stability under the control of mTOR.5
317407862020BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration.9
321154052020The transcription factor Sp1 modulates RNA polymerase III gene transcription by controlling BRF1 and GTF3C2 expression in human cells.9
321980862020The significance of Runx2 mediating alcohol-induced Brf1 expression and RNA Pol III gene transcription.5
328960902020Expanding the phenotype of cerebellar-facial-dental syndrome: Two siblings with a novel variant in BRF1.2
317407862020BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration.9

Citation

Dessen P

BRF1 (BRF1 RNA polymerase III transcription initiation factor subunit)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50104/brf1-(brf1-rna-polymerase-iii-transcription-initiation-factor-subunit)