DACT2 (dishevelled binding antagonist of beta catenin 2)

2008-05-01  

Identity

HGNC
LOCATION
6q27
LOCUSID
ALIAS
C6orf116,DAPPER2,DPR2,bA503C24.7

Other Information

Locus ID:

NCBI: 168002
MIM: 608966
HGNC: 21231
Ensembl: ENSG00000164488

Variants:

dbSNP: 168002
ClinVar: 168002
TCGA: ENSG00000164488
COSMIC: DACT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164488ENST00000366795Q5SW24
ENSG00000164488ENST00000366796Q5SW24
ENSG00000164488ENST00000607983Q5SW24
ENSG00000164488ENST00000610183Q5SW24

Expression (GTEx)

0
5
10
15
20

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
228068262013Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer.28
250237012015DACT2 is a functional tumor suppressor through inhibiting Wnt/β-catenin pathway and associated with poor survival in colon cancer.21
234491222013Epigenetic regulation of the Wnt signaling inhibitor DACT2 in human hepatocellular carcinoma.20
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
269192542016Methylation of DACT2 accelerates esophageal cancer development by activating Wnt signaling.14
238034172013DACT2 is a candidate tumor suppressor and prognostic marker in esophageal squamous cell carcinoma.12
253753592014Methylation of DACT2 promotes papillary thyroid cancer metastasis by activating Wnt signaling.12
277082152016DACT2 silencing by promoter CpG methylation disrupts its regulation of epithelial-to-mesenchymal transition and cytoskeleton reorganization in breast cancer cells.10
255249372015Expression and epigenetic regulation of DACT1 and DACT2 in oral squamous cell carcinoma.9

Citation

Dessen P

DACT2 (dishevelled binding antagonist of beta catenin 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50106/dact2-(dishevelled-binding-antagonist-of-beta-catenin-2)