APOBEC3A (apolipoprotein B mRNA editing enzyme catalytic subunit 3A)

2008-05-01  

Identity

HGNC
APOBEC3A
LOCATION
22q13.1
LOCUSID
200315
ALIAS
A3A,ARP3,PHRBN,bK150C2.1

Other Information

Locus ID:

NCBI: 200315
MIM: 607109
HGNC: 17343
Ensembl: ENSG00000128383

Variants:

dbSNP: 200315
ClinVar: 200315
TCGA: ENSG00000128383
COSMIC: APOBEC3A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128383ENST00000249116P31941
ENSG00000128383ENST00000249116A0A0K0MJ49
ENSG00000128383ENST00000402255P31941
ENSG00000128383ENST00000402255A0A0K0MJ49
ENSG00000128383ENST00000618553P31941
ENSG00000128383ENST00000618553A0A0K0MJ49

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
mRNA EditingREACTOMER-HSA-75072
mRNA Editing: C to U ConversionREACTOMER-HSA-72200
Formation of the EditosomeREACTOMER-HSA-75094

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384995532024Distinguishing preferences of human APOBEC3A and APOBEC3B for cytosines in hairpin loops, and reflection of these preferences in APOBEC-signature cancer genome mutations.2
384995532024Distinguishing preferences of human APOBEC3A and APOBEC3B for cytosines in hairpin loops, and reflection of these preferences in APOBEC-signature cancer genome mutations.2
363940792023APOBEC3A/B deletion polymorphism and endometrial cancer risk.1
366107922023Cellular APOBEC3A deaminase drives mutations in the SARS-CoV-2 genome.17
368897362023The role of APOBEC3A in cervical cancer development and progression: A retrospective study.2
371547472023Apobec3A Deamination Functions Are Involved in Antagonizing Efficient Human Adenovirus Replication and Gene Expression.3
372826212023Seven-membered ring nucleobases as inhibitors of human cytidine deaminase and APOBEC3A.3
372982592023DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo.7
374078182023Therapy-induced APOBEC3A drives evolution of persistent cancer cells.21
374424132023Unraveling the Enzyme-Substrate Properties for APOBEC3A-Mediated RNA Editing.3
374741032023Mitochondrial double-stranded RNA triggers induction of the antiviral DNA deaminase APOBEC3A and nuclear DNA damage.1
380331562023Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer.8
381052912023Regulatory variants of APOBEC3 genes potentially associate with COVID-19 severity in populations with African ancestry.0
363940792023APOBEC3A/B deletion polymorphism and endometrial cancer risk.1
366107922023Cellular APOBEC3A deaminase drives mutations in the SARS-CoV-2 genome.17

Citation

Dessen P

APOBEC3A (apolipoprotein B mRNA editing enzyme catalytic subunit 3A)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50116/apobec3a-(apolipoprotein-b-mrna-editing-enzyme-catalytic-subunit-3a)