APOBEC3B (apolipoprotein B mRNA editing enzyme catalytic subunit 3B)

2008-05-01  

Identity

HGNC
APOBEC3B
LOCATION
22q13.1
LOCUSID
9582
ALIAS
A3B,APOBEC1L,ARCD3,ARP4,DJ742C19.2,PHRBNL,bK150C2.2

Other Information

Locus ID:

NCBI: 9582
MIM: 607110
HGNC: 17352
Ensembl: ENSG00000179750

Variants:

dbSNP: 9582
ClinVar: 9582
TCGA: ENSG00000179750
COSMIC: APOBEC3B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179750ENST00000333467Q9UH17
ENSG00000179750ENST00000335760Q9UH17
ENSG00000179750ENST00000402182B0QYD3
ENSG00000179750ENST00000407298Q9UH17

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
mRNA EditingREACTOMER-HSA-75072
mRNA Editing: C to U ConversionREACTOMER-HSA-72200
Formation of the EditosomeREACTOMER-HSA-75094

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10832corticosteroidsChemicalVariantAnnotationassociatedPD30697902
PA443450AsthmaDiseaseVariantAnnotationassociatedPD30697902

References

Pubmed IDYearTitleCitations
374712652024Action-at-a-distance mutations induced by 8-oxo-7,8-dihydroguanine are dependent on APOBEC3.0
380496642024The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance.8
384995532024Distinguishing preferences of human APOBEC3A and APOBEC3B for cytosines in hairpin loops, and reflection of these preferences in APOBEC-signature cancer genome mutations.2
374712652024Action-at-a-distance mutations induced by 8-oxo-7,8-dihydroguanine are dependent on APOBEC3.0
380496642024The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance.8
384995532024Distinguishing preferences of human APOBEC3A and APOBEC3B for cytosines in hairpin loops, and reflection of these preferences in APOBEC-signature cancer genome mutations.2
363354712023APOBEC3B expression is promoted by lincNMR collaborating with TGF-β-Smad pathway.2
363940792023APOBEC3A/B deletion polymorphism and endometrial cancer risk.1
364163052023Primary mucosal melanomas of the head and neck are characterised by overexpression of the DNA mutating enzyme APOBEC3B.5
367818832023APOBEC3B drives PKR-mediated translation shutdown and protects stress granules in response to viral infection.12
369976612023APOBEC3B stratifies ovarian clear cell carcinoma with distinct immunophenotype and prognosis.1
371900942023Aberrant APOBEC3B Expression in Breast Cancer Is Linked to Proliferation and Cell Cycle Phase.5
372706432023APOBEC3B coordinates R-loop to promote replication stress and sensitize cancer cells to ATR/Chk1 inhibitors.0
375102342023The APOBEC3B c.783delG Truncating Mutation Is Not Associated with an Increased Risk of Breast Cancer in the Polish Population.0
375657482023Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanism.1

Citation

Dessen P

APOBEC3B (apolipoprotein B mRNA editing enzyme catalytic subunit 3B)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50120/apobec3b-(apolipoprotein-b-mrna-editing-enzyme-catalytic-subunit-3b)