Identity
HGNC
LOCATION
22q13.1
LOCUSID
ALIAS
A3B,APOBEC1L,ARCD3,ARP4,DJ742C19.2,PHRBNL,bK150C2.2
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9582
MIM: 607110
HGNC: 17352
Ensembl: ENSG00000179750
Variants:
dbSNP: 9582
ClinVar: 9582
TCGA: ENSG00000179750
COSMIC: APOBEC3B
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000179750 | ENST00000333467 | Q9UH17 |
| ENSG00000179750 | ENST00000335760 | Q9UH17 |
| ENSG00000179750 | ENST00000402182 | B0QYD3 |
| ENSG00000179750 | ENST00000407298 | Q9UH17 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Gene Expression | REACTOME | R-HSA-74160 |
| mRNA Editing | REACTOME | R-HSA-75072 |
| mRNA Editing: C to U Conversion | REACTOME | R-HSA-72200 |
| Formation of the Editosome | REACTOME | R-HSA-75094 |
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10832 | corticosteroids | Chemical | VariantAnnotation | associated | PD | 30697902 | |
| PA443450 | Asthma | Disease | VariantAnnotation | associated | PD | 30697902 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37471265 | 2024 | Action-at-a-distance mutations induced by 8-oxo-7,8-dihydroguanine are dependent on APOBEC3. | 0 |
| 38049664 | 2024 | The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance. | 8 |
| 38499553 | 2024 | Distinguishing preferences of human APOBEC3A and APOBEC3B for cytosines in hairpin loops, and reflection of these preferences in APOBEC-signature cancer genome mutations. | 2 |
| 37471265 | 2024 | Action-at-a-distance mutations induced by 8-oxo-7,8-dihydroguanine are dependent on APOBEC3. | 0 |
| 38049664 | 2024 | The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance. | 8 |
| 38499553 | 2024 | Distinguishing preferences of human APOBEC3A and APOBEC3B for cytosines in hairpin loops, and reflection of these preferences in APOBEC-signature cancer genome mutations. | 2 |
| 36335471 | 2023 | APOBEC3B expression is promoted by lincNMR collaborating with TGF-β-Smad pathway. | 2 |
| 36394079 | 2023 | APOBEC3A/B deletion polymorphism and endometrial cancer risk. | 1 |
| 36416305 | 2023 | Primary mucosal melanomas of the head and neck are characterised by overexpression of the DNA mutating enzyme APOBEC3B. | 5 |
| 36781883 | 2023 | APOBEC3B drives PKR-mediated translation shutdown and protects stress granules in response to viral infection. | 12 |
| 36997661 | 2023 | APOBEC3B stratifies ovarian clear cell carcinoma with distinct immunophenotype and prognosis. | 1 |
| 37190094 | 2023 | Aberrant APOBEC3B Expression in Breast Cancer Is Linked to Proliferation and Cell Cycle Phase. | 5 |
| 37270643 | 2023 | APOBEC3B coordinates R-loop to promote replication stress and sensitize cancer cells to ATR/Chk1 inhibitors. | 0 |
| 37510234 | 2023 | The APOBEC3B c.783delG Truncating Mutation Is Not Associated with an Increased Risk of Breast Cancer in the Polish Population. | 0 |
| 37565748 | 2023 | Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanism. | 1 |
Citation
Dessen P
APOBEC3B (apolipoprotein B mRNA editing enzyme catalytic subunit 3B)
Atlas Genet Cytogenet Oncol Haematol. 2008-05-01
Online version: http://atlasgeneticsoncology.org/gene/50120/apobec3b-(apolipoprotein-b-mrna-editing-enzyme-catalytic-subunit-3b)
