APOBEC3H (apolipoprotein B mRNA editing enzyme catalytic subunit 3H)

2008-05-01  

Identity

HGNC
APOBEC3H
LOCATION
22q13.1
LOCUSID
164668
ALIAS
A3H,ARP-10,ARP10

Other Information

Locus ID:

NCBI: 164668
MIM: 610976
HGNC: 24100
Ensembl: ENSG00000100298

Variants:

dbSNP: 164668
ClinVar: 164668
TCGA: ENSG00000100298
COSMIC: APOBEC3H

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100298ENST00000348946Q6NTF7
ENSG00000100298ENST00000348946B7TQM4
ENSG00000100298ENST00000401756Q6NTF7
ENSG00000100298ENST00000421988A0A087WZI3
ENSG00000100298ENST00000442487Q6NTF7
ENSG00000100298ENST00000442487B7TQM3
ENSG00000100298ENST00000613677Q6NTF7
ENSG00000100298ENST00000613996A0A087WZI3

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
mRNA EditingREACTOMER-HSA-75072
mRNA Editing: C to U ConversionREACTOMER-HSA-72200
Formation of the EditosomeREACTOMER-HSA-75094

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
347745692022Differential Activity of APOBEC3F, APOBEC3G, and APOBEC3H in the Restriction of HIV-2.4
347745692022Differential Activity of APOBEC3F, APOBEC3G, and APOBEC3H in the Restriction of HIV-2.4
327754212020Association between APOBEC3H-Mediated Demethylation and Immune Landscape in Head and Neck Squamous Carcinoma.10
327754212020Association between APOBEC3H-Mediated Demethylation and Immune Landscape in Head and Neck Squamous Carcinoma.10
313221992019Associations between the single nucleotide polymorphisms of APOBEC3A, APOBEC3B and APOBEC3H, and chronic hepatitis B progression and hepatocellular carcinoma in a Chinese population.2
314008562019Different antiviral activities of natural APOBEC3C, APOBEC3G, and APOBEC3H variants against hepatitis B virus.6
315782942019Flexibility in Nucleic Acid Binding Is Central to APOBEC3H Antiviral Activity.6
313221992019Associations between the single nucleotide polymorphisms of APOBEC3A, APOBEC3B and APOBEC3H, and chronic hepatitis B progression and hepatocellular carcinoma in a Chinese population.2
314008562019Different antiviral activities of natural APOBEC3C, APOBEC3G, and APOBEC3H variants against hepatitis B virus.6
315782942019Flexibility in Nucleic Acid Binding Is Central to APOBEC3H Antiviral Activity.6
292906132018The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism.49
293330922018Role of APOBEC3H in the Viral Control of HIV Elite Controller Patients.2
294913872018Understanding the Structure, Multimerization, Subcellular Localization and mC Selectivity of a Genomic Mutator and Anti-HIV Factor APOBEC3H.27
300601962018Structural basis of chimpanzee APOBEC3H dimerization stabilized by double-stranded RNA.20
301352502018APOBEC mutation drives early-onset squamous cell carcinomas in recessive dystrophic epidermolysis bullosa.61

Citation

Dessen P

APOBEC3H (apolipoprotein B mRNA editing enzyme catalytic subunit 3H)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50124/apobec3h-(apolipoprotein-b-mrna-editing-enzyme-catalytic-subunit-3h)