ARG2 (arginase 2)

Identity

HGNC

ARG2

LOCATION

14q24.1

LOCUSID

384

ALIAS

-

FUSION GENES

Show Gene Fusions

Other Information

Locus ID:

NCBI: 384
MIM: 107830
HGNC: 664
Ensembl: ENSG00000081181

Variants:

dbSNP: 384
ClinVar: 384
TCGA: ENSG00000081181
COSMIC: ARG2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000081181	ENST00000261783	P78540
ENSG00000081181	ENST00000261783	A0A024R6A0

Expression (GTEx)

0

10

20

30

40

50

60

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Arginine biosynthesis	KEGG	ko00220
Arginine and proline metabolism	KEGG	ko00330
Arginine biosynthesis	KEGG	hsa00220
Arginine and proline metabolism	KEGG	hsa00330
Metabolic pathways	KEGG	hsa01100
Amoebiasis	KEGG	ko05146
Amoebiasis	KEGG	hsa05146
Urea cycle	KEGG	hsa_M00029
Polyamine biosynthesis, arginine => ornithine => putrescine	KEGG	hsa_M00134
Urea cycle	KEGG	M00029
Polyamine biosynthesis, arginine => ornithine => putrescine	KEGG	M00134
Biosynthesis of amino acids	KEGG	hsa01230
Biosynthesis of amino acids	KEGG	ko01230
Metabolism	REACTOME	R-HSA-1430728
Metabolism of amino acids and derivatives	REACTOME	R-HSA-71291
Urea cycle	REACTOME	R-HSA-70635
Metabolism of polyamines	REACTOME	R-HSA-351202

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15364894	2004	Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension.	132
19508396	2009	Recent advances in arginine metabolism: roles and regulation of the arginases.	128
28614294	2017	Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2.	47
16675494	2006	L-Arginine supplementation or arginase inhibition augments reflex cutaneous vasodilatation in aged human skin.	44
17353439	2007	Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease.	44
19801451	2009	Hypoxia promotes human pulmonary artery smooth muscle cell proliferation through induction of arginase.	44
21130456	2011	OxLDL-dependent activation of arginase II is dependent on the LOX-1 receptor and downstream RhoA signaling.	39
25484082	2014	ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis.	33
16387594	2006	Genetic polymorphisms in arginase I and II and childhood asthma and atopy.	31
23424623	2013	Arginase II expressed in cancer-associated fibroblasts indicates tissue hypoxia and predicts poor outcome in patients with pancreatic cancer.	30

Citation

Dessen P

ARG2 (arginase 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50128/arg2-(arginase-2)