IL32 (interleukin 32)

2008-05-01  

Identity

HGNC
IL32
LOCATION
16p13.3
LOCUSID
9235
ALIAS
IL-32alpha,IL-32beta,IL-32delta,IL-32gamma,NK4,TAIF,TAIFa,TAIFb,TAIFc,TAIFd
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9235
MIM: 606001
HGNC: 16830
Ensembl: ENSG00000008517

Variants:

dbSNP: 9235
ClinVar: 9235
TCGA: ENSG00000008517
COSMIC: IL32

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000008517ENST00000008180P24001
ENSG00000008517ENST00000325568P24001
ENSG00000008517ENST00000382213P24001
ENSG00000008517ENST00000396887P24001
ENSG00000008517ENST00000396890P24001
ENSG00000008517ENST00000440815P24001
ENSG00000008517ENST00000444393P24001
ENSG00000008517ENST00000525228E9PK07
ENSG00000008517ENST00000525377E9PIV2
ENSG00000008517ENST00000525643P24001
ENSG00000008517ENST00000526464P24001
ENSG00000008517ENST00000528163P24001
ENSG00000008517ENST00000529550P24001
ENSG00000008517ENST00000529699C6GKH1
ENSG00000008517ENST00000530538P24001
ENSG00000008517ENST00000530890P24001
ENSG00000008517ENST00000531965P24001
ENSG00000008517ENST00000533097P24001
ENSG00000008517ENST00000534507P24001
ENSG00000008517ENST00000548246P24001
ENSG00000008517ENST00000548476P24001
ENSG00000008517ENST00000548652P24001
ENSG00000008517ENST00000548807F8VSD2
ENSG00000008517ENST00000549213P24001
ENSG00000008517ENST00000551122P24001
ENSG00000008517ENST00000551513F8VVN4
ENSG00000008517ENST00000552356P24001
ENSG00000008517ENST00000552664P24001
ENSG00000008517ENST00000552936F8W1V1
ENSG00000008517ENST00000613483C6GKH1

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
376586852024Modulatory effects of point-mutated IL-32θ (A94V) on tumor progression in triple-negative breast cancer cells.2
382327002024IL32 downregulation lowers triglycerides and type I collagen in di-lineage human primary liver organoids.0
383166972024IL-32 production from lung adenocarcinoma cells is potentially involved in immunosuppressive microenvironment.0
376586852024Modulatory effects of point-mutated IL-32θ (A94V) on tumor progression in triple-negative breast cancer cells.2
382327002024IL32 downregulation lowers triglycerides and type I collagen in di-lineage human primary liver organoids.0
383166972024IL-32 production from lung adenocarcinoma cells is potentially involved in immunosuppressive microenvironment.0
365166532023Diverse and divergent functions of IL-32β and IL-32γ isoforms in the regulation of malignant pleural mesothelioma cell growth and the production of VEGF-A and CXCL8.0
366024252023Impacts of IL-27 and IL-32 in the pathogenesis and outcome of COVID-19 associated mucormycosis.1
369924092023Differential Impact of IL-32 Isoforms on the Functions of Coronary Artery Endothelial Cells: A Potential Link with Arterial Stiffness and Atherosclerosis.1
371053702023IL-32 and its paradoxical role in neoplasia.1
372286102023Human IL-32θA94V mutant attenuates monocyte-endothelial adhesion by suppressing the expression of ICAM-1 and VCAM-1 via binding to cell surface receptor integrin αVβ3 and αVβ6 in TNF-α-stimulated HUVECs.3
372619032023Hepatic interleukin 32 attenuates liver injury through repression of necroptosis in cholestasis.0
373967402023Estimation of Interleukin 32 and Interleukin 37 Serum Levels in Iraqi Patients with Rheumatoid Arthritis.1
376860292023Saturated Fat-Mediated Upregulation of IL-32 and CCL20 in Hepatocytes Contributes to Higher Expression of These Fibrosis-Driving Molecules in MASLD.3
365166532023Diverse and divergent functions of IL-32β and IL-32γ isoforms in the regulation of malignant pleural mesothelioma cell growth and the production of VEGF-A and CXCL8.0

Citation

Dessen P

IL32 (interleukin 32)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50130/tumors-explorer/humanGenome