IRF8 (interferon regulatory factor 8)

2008-05-01  

Identity

HGNC
IRF8
LOCATION
16q24.1
LOCUSID
3394
ALIAS
H-ICSBP,ICSBP,ICSBP1,IMD32A,IMD32B,IRF-8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3394
MIM: 601565
HGNC: 5358
Ensembl: ENSG00000140968

Variants:

dbSNP: 3394
ClinVar: 3394
TCGA: ENSG00000140968
COSMIC: IRF8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140968ENST00000268638Q02556
ENSG00000140968ENST00000562492H3BPS5
ENSG00000140968ENST00000563180H3BVC2
ENSG00000140968ENST00000564617H3BQH6
ENSG00000140968ENST00000564803H3BT31
ENSG00000140968ENST00000565552H3BQK3
ENSG00000140968ENST00000566369H3BNX4
ENSG00000140968ENST00000569145H3BQF9
ENSG00000140968ENST00000569607H3BRT4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
PertussisKEGGko05133
PertussisKEGGhsa05133
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384818032024WTAP Mediated N6-methyladenosine RNA Modification of ELF3 Drives Cellular Senescence by Upregulating IRF8.0
384818032024WTAP Mediated N6-methyladenosine RNA Modification of ELF3 Drives Cellular Senescence by Upregulating IRF8.0
366722462023IRF8 Regulates Intrinsic Ferroptosis through Repressing p53 Expression to Maintain Tumor Cell Sensitivity to Cytotoxic T Lymphocytes.3
367030052023Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF.3
369594842023Loss of IRF8 inhibits the growth of acute myeloid leukemia cells.0
375085552023Expression of Interferon Regulatory Factor 8 (IRF8) and Its Association with Infections in Dialysis Patients.0
375917142023Circulating IRF8-expressing CD123(+)CD127(+) lymphoid progenitors: key players in human hematopoiesis.2
366722462023IRF8 Regulates Intrinsic Ferroptosis through Repressing p53 Expression to Maintain Tumor Cell Sensitivity to Cytotoxic T Lymphocytes.3
367030052023Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF.3
369594842023Loss of IRF8 inhibits the growth of acute myeloid leukemia cells.0
375085552023Expression of Interferon Regulatory Factor 8 (IRF8) and Its Association with Infections in Dialysis Patients.0
375917142023Circulating IRF8-expressing CD123(+)CD127(+) lymphoid progenitors: key players in human hematopoiesis.2
343316642022IRF4 and IRF8 expression are associated with clinical phenotype and clinico-hematological response to hydroxyurea in essential thrombocythemia.2
349914672022Predicting the targets of IRF8 and NFATc1 during osteoclast differentiation using the machine learning method framework cTAP.1
350855992022Global assessment of IRF8 as a novel cancer biomarker.3

Citation

Dessen P

IRF8 (interferon regulatory factor 8)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50137