CD163 (CD163 molecule)

2008-05-01  

Identity

HGNC
CD163
LOCATION
12p13.31
LOCUSID
9332
ALIAS
M130,MM130,SCARI1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9332
MIM: 605545
HGNC: 1631
Ensembl: ENSG00000177575

Variants:

dbSNP: 9332
ClinVar: 9332
TCGA: ENSG00000177575
COSMIC: CD163

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177575ENST00000359156Q86VB7
ENSG00000177575ENST00000396620C9JHR8
ENSG00000177575ENST00000432237Q86VB7
ENSG00000177575ENST00000537626H0YFM0
ENSG00000177575ENST00000541972F5GZZ9
ENSG00000177575ENST00000542280H0YGZ7

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Binding and Uptake of Ligands by Scavenger ReceptorsREACTOMER-HSA-2173782
Scavenging of heme from plasmaREACTOMER-HSA-2168880

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
146569262004Hemoglobin scavenger receptor CD163 mediates interleukin-10 release and heme oxygenase-1 synthesis: antiinflammatory monocyte-macrophage responses in vitro, in resolving skin blisters in vivo, and after cardiopulmonary bypass surgery.130
188494842009The macrophage scavenger receptor CD163 functions as an innate immune sensor for bacteria.116
220607472012Soluble CD163.96
165078982006CD163 identifies perivascular macrophages in normal and viral encephalitic brains and potential precursors to perivascular macrophages in blood.92
195283712009Macrophage markers in serum and tumor have prognostic impact in American Joint Committee on Cancer stage I/II melanoma.89
161892772006CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin.82
175486572007A previously unrecognized protein-protein interaction between TWEAK and CD163: potential biological implications.69
191315492009Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification.69
232894762013Expression of M2-polarized macrophages is associated with poor prognosis for advanced epithelial ovarian cancer.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62

Citation

Dessen P

CD163 (CD163 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50148/cd163-(cd163-molecule)