SGTA (small glutamine rich tetratricopeptide repeat co-chaperone alpha)

2008-05-01  

Identity

HGNC
SGTA
LOCATION
19p13.3
LOCUSID
6449
ALIAS
SGT,alphaSGT,hSGT
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6449
MIM: 603419
HGNC: 10819
Ensembl: ENSG00000104969

Variants:

dbSNP: 6449
ClinVar: 6449
TCGA: ENSG00000104969
COSMIC: SGTA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104969ENST00000221566O43765
ENSG00000104969ENST00000587866K7ERW5
ENSG00000104969ENST00000589251K7EMD6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
358957112022USP5 enhances SGTA mediated protein quality control.0
358957112022USP5 enhances SGTA mediated protein quality control.0
337575752021SGTA associates with intracellular aggregates in neurodegenerative diseases.2
337575752021SGTA associates with intracellular aggregates in neurodegenerative diseases.2
322160162020SGTA associates with nascent membrane protein precursors.16
322160162020SGTA associates with nascent membrane protein precursors.16
306350832019The roles of cytosolic quality control proteins, SGTA and the BAG6 complex, in disease.10
306350832019The roles of cytosolic quality control proteins, SGTA and the BAG6 complex, in disease.10
299968282018Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control.7
299968282018Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control.7
283565242017SGTA-Dependent Regulation of Hsc70 Promotes Cytosol Entry of Simian Virus 40 from the Endoplasmic Reticulum.24
283565242017SGTA-Dependent Regulation of Hsc70 Promotes Cytosol Entry of Simian Virus 40 from the Endoplasmic Reticulum.24
271033332016The Vpu-interacting Protein SGTA Regulates Expression of a Non-glycosylated Tetherin Species.7
278274102016SGTA interacts with the proteasomal ubiquitin receptor Rpn13 via a carboxylate clamp mechanism.8
271033332016The Vpu-interacting Protein SGTA Regulates Expression of a Non-glycosylated Tetherin Species.7

Citation

Dessen P

SGTA (small glutamine rich tetratricopeptide repeat co-chaperone alpha)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50154/sgta-(small-glutamine-rich-tetratricopeptide-repeat-co-chaperone-alpha)